Molecular Communication from Skeletal Muscle to Bone: A Review for Muscle-Derived Myokines Regulating Bone Metabolism

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• 作者：Baosheng Guo ; Zong-Kang Zhang ; Chao Liang ; Jie Li…
• 关键词：Skeletal muscle ; Bone ; Myokines
• 刊名：Calcified Tissue International
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：100
• 期：2
• 页码：184-192
• 全文大小：
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biochemistry, general; Endocrinology; Orthopedics; Cell Biology;
• 出版者：Springer US
• ISSN：1432-0827
• 卷排序：100

文摘

Besides the mechanical loading-dependent paradigm, skeletal muscle also serves as an endocrine organ capable of secreting cytokines to modulate bone metabolism. In this review, we focused on reviewing the myokines involved in communication from skeletal muscle to bone, i.e. (1) myostatin and myostatin-binding proteins including follistatin and decorin, (2) interleukins including interleukin-6 (IL-6), interleukin-7 (IL-7) and interleukin-15 (IL-15), (3) insulin-like growth factor 1 (IGF-1) and its binding proteins, (4) other myokines including PGC-1α-irisin system and osteoglycin (OGN). To better understand the molecular communication from skeletal muscle to bone, we have summarized the recent advances in muscle-derived cytokines regulating bone metabolism in this review.