Absence of DNA damage after 60-Hz electromagnetic field exposure combined with ionizing radiation, hydrogen peroxide, or c-Myc overexpression

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• 作者：Yeung Bae Jin (1)
  Seo-Hyun Choi (2)
  Jae Seon Lee (2)
  Jae-Kyung Kim (1)
  Ju-Woon Lee (1)
  Seung-Cheol Hong (3)
  Sung Ho Myung (4)
  Yun-Sil Lee (5)
  
• 关键词：Extremely low frequency ; Combined treatment ; Comet olive tail moment for DNA damage
• 刊名：Radiation and Environmental Biophysics
• 出版年：2014
• 出版时间：March 2014
• 年：2014
• 卷：53
• 期：1
• 页码：93-101
• 全文大小：871 KB
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• 作者单位：Yeung Bae Jin (1)
  Seo-Hyun Choi (2)
  Jae Seon Lee (2)
  Jae-Kyung Kim (1)
  Ju-Woon Lee (1)
  Seung-Cheol Hong (3)
  Sung Ho Myung (4)
  Yun-Sil Lee (5)
  
  1. Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup, Korea
  2. Korea Institute of Radiological and Medical Sciences, Seoul, 139-706, Korea
  3. Department of Occupational Health and Safety Engineering, Inje University, Pusan, Korea
  4. Power Systems Research Division, Electrical Environment Team, Korea Electrotechnology Research Institute, Changwon, Korea
  5. Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul, 120-750, Korea
  
• ISSN：1432-2099

文摘

The principal objective of this study was to assess the DNA damage in a normal cell line system after exposure to 60?Hz of extremely low frequency magnetic field (ELF-MF) and particularly in combination with various external factors, via comet assays. NIH3T3 mouse fibroblast cells, WI-38 human lung fibroblast cells, L132 human lung epithelial cells, and MCF10A human mammary gland epithelial cells were exposed for 4 or 16?h to a 60-Hz, 1?mT uniform magnetic field in the presence or absence of ionizing radiation (IR, 1?Gy), H2O2 (50?μM), or c-Myc oncogenic activation. The results obtained showed no significant differences between the cells exposed to ELF-MF alone and the unexposed cells. Moreover, no synergistic or additive effects were observed after 4 or 16?h of pre-exposure to 1?mT ELF-MF or simultaneous exposure to ELF-MF combined with IR, H2O2, or c-Myc activation.