Use of a low-dose prednisolone regimen to treat a relapse of steroid-sensitive nephrotic syndrome in children

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• 作者：Karnika Raja ; Ami Parikh ; Hazel Webb ; Daljit Hothi
• 关键词：Steroid ; sensitive nephrotic syndrome (SSNS) ; Low ; dose prednisolone ; PedsQL
• 刊名：Pediatric Nephrology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：32
• 期：1
• 页码：99-105
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Pediatrics; Nephrology; Urology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-198X
• 卷排序：32

文摘

BackgroundRelapses of nephrotic syndrome are common and are treated with a course of prednisolone (2 mg/kg/day or 60 mg/m2/day). This is associated with major adverse effects including diabetes, weight gain, hypertension and behavioural problems. This study is a retrospective review examining the success of treating relapses in steroid-sensitive nephrotic syndrome (SSNS) with low-dose prednisolone and the consequences on subsequent relapse rates. Furthermore, a follow-up study looked at the side-effect profile during treatment with high- versus low-dose prednisolone.