Artefactual origin of biphasic cortical spike-LFP correlation

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• 作者：Michael Okun
• 关键词：Phase distortion ; Extracellular amplifier ; Neural probes ; Silicon probes ; Neural data acquisition
• 刊名：Journal of Computational Neuroscience
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：42
• 期：1
• 页码：31-35
• 全文大小：998KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Neurosciences; Neurology; Human Genetics; Theory of Computation;
• 出版者：Springer US
• ISSN：1573-6873
• 卷排序：42

文摘

Electrophysiological data acquisition systems introduce various distortions into the signals they record. While such distortions were discussed previously, their effects are often not appreciated. Here I show that the biphasic shape of cortical spike-triggered LFP average (stLFP), reported in multiple studies, is likely an artefact introduced by high-pass filter of the neural data acquisition system when the actual stLFP has a single trough around the zero lag.