The Efficacy of Neurofeedback in Patients with Major Depressive Disorder: An Open Labeled Prospective Study

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• 作者：Eun-Jin Cheon ; Bon-Hoon Koo ; Joong-Hyun Choi
• 关键词：Neurofeedback ; Beta training ; Depression ; Asymmetry score
• 刊名：Applied Psychophysiology and Biofeedback
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：41
• 期：1
• 页码：103-110
• 全文大小：422 KB
• 参考文献：American Psychiatric Association. (2000). Diagnostic criteria from DSM-IV-TR. Washington, D.C.: American Psychiatric Association.
  Baehr, E., & Baehr, R. (1997). The use of neurofeedback as adjunctive therapeutic treatment for depression: Three case studies. Biofeedback, 25, 10–11.
  Baehr, E., Rosenfeld, J. P., & Baehr, R. (2001). Clinical use of an alpha asymmetry neurofeedback protocol in the treatment of mood disorders: Follow-up study one to five years post therapy. Journal of Neurotherapy, 4(4), 11–18.CrossRef
  Bagby, R. M., Ryder, A. G., Schuller, D. R., & Marshall, M. B. (2006). The Hamilton depression rating scale: Has the gold standard become a lead weight? The American Journal of Psychiatry, 161, 2163–2177.CrossRef
  Baxter, L. R. Jr., Schwartz, J. M., Phelps, M. E., Mazziotta, J. C., Guze, B. H., Selin, C. E., et al. (1989). Reduction of prefrontal cortex glucose metabolism common to three types of depression. Archives of General Psychiatry, 46(3), 243–250.
  Beck, A. T., & Steer, R. A. (1990). Beck anxiety inventory manual. San Antonio, TX: Psychological Corporation.
  Beck, A. T., Steer, R. A., & Brown, G. K. (1996). Manual for beck depression inventory-II. San Antonio, TX: Psychological Corporation.
  Bench, C. J., Friston, K. J., Brown, R. G., Frackowiak, R. S., & Dolan, R. J. (1993). Regional cerebral blood flow in depression measured by positron emission tomography: The relationship with clinical dimensions. Psychological Medicine, 23(3), 579–590.CrossRef PubMed
  Bench, C. J., Friston, K. J., Brown, R. G., Scott, L. C., Frackowiak, R. S., & Dolan, R. J. (1992). The anatomy of melancholia–focal abnormalities of cerebral blood flow in major depression. Psychological Medicine, 22(3), 607–615.CrossRef PubMed
  Bonnet, M. H., & Arand, D. L. (2001). Impact of activity and arousal upon spectral EEG parameters. Physiology & Behavior, 74(3), 291–298.CrossRef
  Bouyer, J. J., Montaron, M. F., Vahnée, J. M., Albert, M. P., & Rougeul, A. (1987). Anatomical localization of cortical beta rhythms in cat. Neuroscience, 22(3), 863–869.CrossRef PubMed
  Brody, A. L., Barsom, M. W., Bota, R. G., & Saxena, S. (2001). Prefrontal-subcortical and limbic circuit mediation of major depressive disorder. Seminars in Clinical Neuropsychiatry, 6(2), 102–112.CrossRef PubMed
  Busner, J., & Targum, S. D. (2007). The clinical global impressions scale: Applying a research tool in clinical practice. Psychiatry (Edgmont), 4(7), 28–37.
  Busner, J., Targum, S. D., & Miller, D. S. (2009). The clinical global impressions scale: Errors in understanding and use. Comprehensive Psychiatry, 50(3), 257–262. doi:10.​1016/​j.​comppsych.​2008.​08.​005 .CrossRef PubMed
  Cheon, E. J., Koo, B. H., Seo, W. S., Lee, J. Y., Choi, J. H., & Song, S. H. (2015). Effects of neurofeedback on adult patients with psychiatric disorders in a naturalistic setting. Applied Psychophysiology and Biofeedback, 40(1), 17–24. doi:10.​1007/​s10484-015-9269-x .CrossRef PubMed
  Choi, S. W., Chi, S. E., Chung, S. Y., Kim, J. W., Ahn, C. Y., & Kim, H. T. (2011). Is alpha wave neurofeedback effective with randomized clinical trials in depression? A pilot study. Neuropsychobiology, 63(1), 43–51. doi:10.​1159/​000322290 .CrossRef PubMed
  Conca, A., Koppi, S., Konig, P., Swoboda, E., & Krecke, N. (1996). Transcranial magnetic stimulation: A novel antidepressive strategy? Neuropsychobiology, 34(4), 204–207.CrossRef PubMed
  Davidson, R. J. (1998). Anterior electrophysiological asymmetries, emotion, and depression: Conceptual and methodological conundrums. Psychophysiology, 35(5), 607–614.CrossRef PubMed
  Davidson, R. J., & Henriques, J. B. (2000). Regional brain function in sadness and depression. In J. Borod (Ed.), The neuropsychology of emotion (pp. 269–297). New York: Oxford University Press.
  Dias, A. M., & van Deusen, A. (2011). A new neurofeedback protocol for depression. The Spanish Journal of Psychology, 14(1), 374–384.CrossRef PubMed
  Drevets, W. C., Price, J. L., Simpson, J. R., Todd, R. D., Reich, T., Vannier, M., et al. (1997). Subgenual prefrontal cortex abnormalities in mood disorders. Nature, 386, 824–827.CrossRef PubMed
  Drevets, W. C., Videen, T. O., Price, J. L., Preskorn, S. H., Carmichael, S. T., & Raichle, M. E. (1992). A functional anatomical study of unipolar depression. The Journal of Neuroscience, 12, 3628–3641.PubMed
  Earnest, C. (1999). Single case study of EEG asymmetry biofeedback for depression: An independent replication in an adolescent. Journal of Neurotherapy, 3(2), 28–35.CrossRef
  Galynker, I. I., Cai, J., Ongseng, F., Finestone, H., Dutta, E., & Serseni, D. (1998). Hypofrontality and negative symptoms in major depressive disorder. The Journal of Nuclear Medicine, 39(4), 608–612.PubMed
  George, M. S., Wassermann, E. M., Williams, W. A., Callahan, A., Ketter, T. A., Basser, P., et al. (1995). Daily repetitive transcranial magnetic stimulation (rTMS) improves mood in depression. NeuroReport, 6(14), 1853–1856.CrossRef PubMed
  Gruzelier, J. (2009). A theory of alpha/theta neurofeedback, creative performance enhancement, long distance functional connectivity and psychological integration. Cognitive Processing, 10(Suppl 1), S101–S109. doi:10.​1007/​s10339-008-0248-5 . (Epub 2008 Dec 11).CrossRef PubMed
  Hamilton, M. (1959). The assessment of anxiety states by rating. British Journal of Medical Psychology, 32, 50–55.CrossRef PubMed
  Hammond, D. C. (2000). Neurofeedback treatment of depression with the Roshi. Journal of Neurotherapy, 4(2), 45–56.CrossRef
  Hammond, D. C. (2005). Neurofeedback treatment of depression and anxiety. Journal of Adult Development, 12(2), 131–137.CrossRef
  Henriques, J. B., & Davidson, R. J. (1990). Regional brain electrical asymmetries discriminate between previously depressed and healthy control subjects. Journal of Abnormal Psychology, 99(1), 22–31.CrossRef PubMed
  Kato, T., Shioiri, T., Murashita, J., Hamakawa, H., Takahashi, Y., Inubushi, T., et al. (1995). Lateralized abnormality of high energy phosphate metabolism in the frontal lobes of patients with bipolar disorder detected by phase-encoded 31P-MRS. Psychological Medicine, 25, 557–566.CrossRef PubMed
  Kung, S., Alarcon, R. D., Williams, M. D., Poppe, K. A., Jo Moore, M., & Frye, M. A. (2013). Comparing the Beck Depression Inventory-II (BDI-II) and Patient Health Questionnaire (PHQ-9) depression measures in an integrated mood disorders practice. Journal of Affective Disorder, 145(3), 341–343. doi:10.​1016/​j.​jad.​2012.​08.​017 .CrossRef
  Larsen, S., & Sherlin, L. (2013). Neurofeedback an emerging technology for treating central nervous system dysregulation. Psychiatric Clininics of North America, 36, 163–168.CrossRef
  Leyfer, O. T., Ruberg, J. L., & Woodruff-Borden, J. (2006). Examination of the utility of the Beck Anxiety Inventory and its factors as a screener for anxiety disorders. Journal of Anxiety Disorders, 20(4), 444–458.CrossRef PubMed
  Martinot, J. L., Hardy, P., Feline, A., Huret, J. D., Mazoyer, B., Attar-Levy, D., et al. (1990). Left prefrontal glucose hypometabolism in the depressed state: A confirmation. The American Journal of Psychiatry, 147(10), 1313–1317.CrossRef PubMed
  Mayberg, H. S. (2003). Modulating dysfunctional limbic-cortical circuits in depression: Towards development of brain-based algorithms for diagnosis and optimised treatment. British Medical Bulletin, 65, 193–207.CrossRef PubMed
  Murthy, V. N., & Fetz, E. E. (1992). Coherent 25- to 35-Hz oscillations in the sensorimotor cortex of awake behaving monkeys. Proceedings of the National Academy of Sciences of the United States of America, 89(12), 5670−5674.
  Niv, S. (2013). Clinical efficacy and potential mechanisms of neurofeedback. Personality and Individual Differences, 54(6), 676–686. doi:10.​1016/​j.​paid.​2012.​11.​037 .CrossRef
  Osman, A., Barrios, F. X., Aukes, D., Osman, J. R., & Markway, K. (1993). The Beck Anxiety Inventory: Psychometric properties in a community population. Journal of Psychopathology and Behavioral Assessment, 15, 287–297.CrossRef
  Osuch, E. A., Ketter, T. A., Kimbrell, T. A., George, M. S., Benson, B. E., Willis, M. W., et al. (2000). Regional cerebral metabolism associated with anxiety symptoms in affective disorder patients. Biological Psychiatry, 48, 1020–1023.CrossRef PubMed
  Pascual-Leone, A., Peris, M., Tormos, J. M., Pascual, A. P., & Catala, M. D. (1996). Reorganization of human cortical motor output maps following traumatic forearm amputation. NeuroReport, 7(13), 2068–2070.CrossRef PubMed
  Paus, T., Castro-Alamancos, M. A., & Petrides, M. (2001). Cortico-cortical connectivity of the human mid-dorsolateral frontal cortex and its modulation by repetitive transcranial magnetic stimulation. European Journal of Neuroscience, 14(8), 1405–1411.CrossRef PubMed
  Peniston, E. G., & Kulkosky, P. J. (1989). Alpha-theta brainwave training and beta-endorphin levels in alcoholics. Alcoholism Clininical and Experimental Research, 13(2), 271–279.CrossRef
  Reischies, F. M., Hedde, J. P., & Drochner, R. (1989). Clinical correlates of cerebral blood flow in depression. Psychiatry Research, 29(3), 323–326.CrossRef PubMed
  Rosenfeld, J. P. (1997). EEG biofeedback of frontal alpha asymmetry in affective disorders. Biofeedback, 25(1), 8–25.
  Rosenfeld, J. P. (2000). An EEG biofeedback protocol for affective disorders. Clinical Electroencephalography, 31(1), 7–12.CrossRef PubMed
  Rosenfeld, J. P., Cha, G., Blair, T., & Gotlib, I. H. (1995). Operant (biofeedback) control of left-right frontal alpha power differences: Potential neurotherapy for affective disorders. Biofeedback Self Regulation, 20(3), 241–258.CrossRef PubMed
  Rush, A. J., Trivedi, M. H., Ibrahim, H. M., Carmody, T. J., Arnow, B., Klein, D. N., et al. (2003). The 16-item quick inventory of depressive symptomatology (QIDS), clinician rating (QIDS-C), and self-report (QIDSSR): A psychometric evaluation in patients with chronic major depression. Biological Psychiatry, 54, 573–583.CrossRef PubMed
  Rush, A. J., Trivedi, M. H., Stewart, J. W., Nierenberg, A. A., Fava, M., Kurian, B. T., & Wisniewski, S. R. (2011). Combining medications to enhance depression outcomes (CO-MED): Acute and long-term outcomes of a single-blind randomized study. The American Journal of Psychiatry, 168(7), 689–701. doi:10.​1176/​appi.​ajp.​2011.​10111645 .CrossRef PubMed
  Saxby, E., & Peniston, E. G. (1995). Alpha-theta brainwave neurofeedback training: An effective treatment for male and female alcoholics with depressive symptoms. Journal of Clinical Psychology, 51(5), 685–693.CrossRef PubMed
  Scott, W. C., Kaiser, D., Othmer, S., & Sideroff, S. I. (2005). Effects of an EEG biofeedback protocol on a mixed substance abusing population. The American Journal of Drug and Alcohol Abuse, 31(3), 455–469.CrossRef PubMed
  Shear, M. K., Vander Bilt, J., Rucci, P., Endicott, J., Lydiard, B., Otto, M. W., & Frank, D. M. (2001). Reliability and validity of a structured interview guide for the Hamilton anxiety rating scale (SIGH-A). Depression and Anxiety, 13(4), 166–178.CrossRef PubMed
  Tomarken, A. J., Davidson, R. J., Wheeler, R. E., & Kinney, L. (1992). Psychometric properties of resting anterior EEG asymmetry: Temporal stability and internal consistency. Psychophysiology, 29(5), 576–592.CrossRef PubMed
  United States, Depression Guideline Panel, & United States, Agency for Health Care Policy and Research. (1993). Depression in primary care. Rockville, Md. Washington, D.C: U.S. Dept. of Health and Human Services.
  Walker, J. E., & Lawson, R. (2013). FP02 beta training for drug-resistant depression—a new protocol that usually reduces depression and keeps it reduced. Journal of Neurotherapy, 17, 198–200.CrossRef
  Walker, J. E., Lawson, R., & Kozlowski, G. (2007). Current status of QEEG and neurofeedback in the treatment of clinical depression. In J. R. Evans (Ed.), The handbook of neurofeedback (pp. 341–351). Binghampton, NY: Haworth Medical Press.CrossRef
  Zimmerman, M., Chelminski, I., & Posternak, M. (2004). A review of studies of the Hamilton depression rating scale in healthy controls: Implications for the definition of remission in treatment studies of depression. The Journal of Nervous and Mental Disease, 192(9), 595–601.CrossRef PubMed
  
• 作者单位：Eun-Jin Cheon (1)
  Bon-Hoon Koo (1)
  Joong-Hyun Choi (2)
  
  1. Department of Psychiatry, Yeungnam University College of Medicine,Yeungnam University Medical Center, 317-1, Daemyeong 5-dong, Nam-gu, Daegu, Republic of Korea
  2. Department of Psychology, Yeungnam University College of Medicine,Yeungnam University Medical Center, Daegu, Republic of Korea
  
• 刊物类别：Behavioral Science
• 刊物主题：Psychology
  Psychology
  Health Psychology
  Stress and Coping
  Public Health
  
• 出版者：Springer Netherlands
• ISSN：1573-3270

文摘

The purpose of this study was to evaluate the effect of neurofeedback on depressive symptoms and electrophysiological disturbances in patients with major depressive disorder. We recruited participants suffering from depression to evaluate efficacy of left prefrontal beta with alpha/theta training. An 8-week, prospective, open-label study was undertaken. Twenty participants were recruited. The treatment protocol was twice or three times a week training of beta at F3 with alpha/theta at Pz for 8 weeks. When every visit, patients were received beta training for 30 min, and then alpha/theta training for 30 min. Baseline, 4 and 8 week scores of; the Hamilton rating scale for Depression (HAM-D), the Hamilton rating scale for Anxiety (HAM-A), the Beck Depression Inventory (BDI)-II, the Beck Anxiety Inventory (BAI), Clinical global impression-severity (CGI-S), and pre- and post-treatment resting state EEGs were compared. Interhemispheric alpha power asymmetry (A score) was computed for homologous sites F3–F4. Pre- and post-training clinical assessments revealed significant improvements in HAM–D, HAM-A, BDI, and CGI-S scores. Cumulative response rates by HAM-D were 35.0 and 75.0 % at 4 and 8 weeks, respectively, corresponding cumulative remission rates by HAM-D were 15.0 and 55.0 %, respectively. No significant differences were found between pre- and post-treatment A score. Neurofeedback treatment could improve depressive symptoms significantly. In addition, anxiety symptoms and clinical illness severity decreased significantly after neurofeedback treatment. Despite its several limitations, such as, small sample size and lack of a control group, this study suggested neurofeedback has significant effects in patients with major depressive disorder. Keywords Neurofeedback Beta training Depression Asymmetry score