Gene-environment interaction between lead and Apolipoprotein E4 causes cognitive behavior deficits in mice
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- 作者：Anna K. Engstrom ; Jessica M. Snyder ; Nobuyo Maeda…
- 关键词：Lead ; Apolipoprotein E ; Cognitive behavior ; Adult hippocampal neurogenesis ; Learning and memory
- 刊名：Molecular Neurodegeneration
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：12
- 期：1
- 全文大小：5941KB
- 刊物主题：Neurosciences; Neurology; Molecular Medicine;
- 出版者：BioMed Central
- ISSN：1750-1326
- 卷排序：12
文摘
BackgroundAlzheimer’s disease (AD) is characterized by progressive cognitive decline and memory loss. Environmental factors and gene-environment interactions (GXE) may increase AD risk, accelerate cognitive decline, and impair learning and memory. However, there is currently little direct evidence supporting this hypothesis.