PEGylated liposomes prepared with polyborane instead of cholesterol for BNCT: characteristics and biodistribution evaluation
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- 作者：Issei Takeuchi ; Keishiro Tomoda ; Koji Matsumoto…
- 关键词：Boron neutron capture therapy ; PEGylation ; Liposomes ; Drug delivery ; Dicarba ; closo ; dodecaborane ; Biodistribution
- 刊名：Colloid & Polymer Science
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：294
- 期：10
- 页码：1679-1685
- 全文大小：718 KB
- 刊物类别：Chemistry and Materials Science
- 刊物主题：Chemistry
Polymer Sciences
Physical Chemistry
Soft Matter and Complex Fluids
Characterization and Evaluation Materials
Food Science - 出版者：Springer Berlin / Heidelberg
- ISSN：1435-1536
- 卷排序：294
文摘
Recently, boron neutron capture therapy (BNCT) has been focused on, which is a cancer therapy using nuclear reaction between boron and thermal neutron. To selectively destroy cancer cells, the high accumulation and selective delivery of boron-10 (10B) into tumor tissue are required. We have developed polyborane from 1,7-dicarba-closo-dodecaborane as a boron carrier. To evaluate tumor accumulation of polyborane, PEGylated liposomes were chosen as carrier. The mean volume diameters of polyborane-embedded liposomes were 50, 100, and 200 nm, respectively. They were injected into the tail vein of tumor-bearing mice. Twenty-four hours later, mice were killed and biodistribution of boron was determined using the inductively coupled plasma atomic emission spectrometry. At 24 h after injection, 50 nm bare liposome and 100 nm PEGylated liposome were found in tumor with high boron levels. Moreover, 50 nm bare liposome showed high tumor/blood ratios of boron concentration, and their usability for BNCT was suggested.