Evaluation of a novel sodium borocaptate-containing unnatural amino acid as a boron delivery agent for neutron capture therapy of the F98 rat glioma

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• 作者：Gen Futamura ; Shinji Kawabata ; Naosuke Nonoguchi ; Ryo Hiramatsu…
• 关键词：Boron neutron capture therapy ; F98 rat glioma model ; ACBC ; BSH
• 刊名：Radiation Oncology
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：12
• 期：1
• 全文大小：2344KB
• 刊物主题：Cancer Research; Oncology; Radiotherapy; Imaging / Radiology;
• 出版者：BioMed Central
• ISSN：1748-717X
• 卷排序：12

文摘

BackgroundBoron neutron capture therapy (BNCT) is a unique particle radiation therapy based on the nuclear capture reactions in boron-10. We developed a novel boron-10 containing sodium borocaptate (BSH) derivative, 1-amino-3-fluorocyclobutane-1-carboxylic acid (ACBC)-BSH. ACBC is a tumor selective synthetic amino acid. The purpose of this study was to assess the biodistribution of ACBC-BSH and its therapeutic efficacy following Boron Neutron Capture Therapy (BNCT) of the F98 rat glioma.