Influence of miR-30b regulating humoral immune response by genetic difference

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• 作者：Zhi-Qing Duan ; Jian-Dong Shi ; Mei-Ni Wu ; Ning-Zhu Hu ; Yun-Zhang Hu
• 关键词：Genetic difference ; MiR ; 30b ; B lymphoma cell ; L ; Kynurenine
• 刊名：Immunologic Research
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：64
• 期：1
• 页码：181-190
• 全文大小：2,264 KB
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• 作者单位：Zhi-Qing Duan (1) (2)
  Jian-Dong Shi (3)
  Mei-Ni Wu (3)
  Ning-Zhu Hu (3)
  Yun-Zhang Hu (3)
  
  1. Shanxi Medical University, 56 South Xinjian Road, Taiyuan, 030001, Shanxi, People’s Republic of China
  2. The Second Hospital of Shanxi Medical University, 382 Wuyi Road, Taiyuan, 030001, Shanxi, People’s Republic of China
  3. Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, 935 Jiaoling Road, Kunming, 650118, Yunnan, People’s Republic of China
  
• 刊物主题：Allergology; Immunology; Medicine/Public Health, general; Internal Medicine;
• 出版者：Springer US
• ISSN：1559-0755

文摘

Investigation of genetic difference will be beneficial to researchers to understand the origins and nature of diseases. Previous studies have revealed that L-kynurenine (L-Kyn) level was changed significantly in patient with cancer and that miR-30b play different role in tumor cells and immune cells. Moreover, it has been also conformed that miR-30b involved in the process of L-Kyn-mediated suppression of humoral immune responses induced by lipopolysaccharide (LPS) in human normal B cells separated from volunteers’ peripheral blood. Nevertheless, the miR-30b role regulating humoral immune response in B lymphoma cells has been still unclear due to the genetic difference between normal cells and tumor cells. The current study demonstrated that the selected concentration of L-Kyn (100, 1000 μM) significantly reduced the immunoglobulin M secretion induced by LPS when compared with the control group in B lymphoma, CH12.LX, and BCL-1 cells, which had, at least, incomplete dependence on Aryl hydrocarbon receptor, the receptor of L-Kyn. In addition, although L-Kyn (100 μM) significantly attenuated the expression of miR-30b in BCL-1 cells rather than in CH12.LX cells, no significant differences in the strength of L-Kyn-mediated suppression of humoral immune responses induced by LPS were detected by enzyme-linked immunosorbent assay between the LPS (10 μg/ml) + L-Kyn (100 μM) group and the LPS (10 μg/ml) + L-Kyn (100 μM) + miR-30b mimics/miR-30b inhibitor group in CH12.LX and BCL-1 cells, respectively. Further data also showed that mouse Bach2 mRNA was a novel target of miR-30b. These results suggest that genetic difference among cells has a great influence on the miR-30b role in the process of L-Kyn-mediated suppression of humoral immune responses induced by LPS. Keywords Genetic difference MiR-30b B lymphoma cell L-Kynurenine