Solubilization and Interaction Studies of Bile Salts with Surfactants and Drugs: a Review

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• 作者：Nisar Ahmad Malik
• 刊名：Applied Biochemistry and Biotechnology
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：179
• 期：2
• 页码：179-201
• 全文大小：1,581 KB
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Biotechnology
  Biochemistry
  
• 出版者：Humana Press Inc.
• ISSN：1559-0291
• 卷排序：179

文摘

In this review, bile salt, bile salt–surfactant, and bile salt–drug interactions and their solubilization studies are mainly focused. Usefulness of bile salts in digestion, absorption, and excretion of various compounds and their rare properties in ordering the shape and size of the micelles owing to the presence of hydrophobic and hydrophilic faces are taken into consideration while compiling this review. Bile salts as potential bio-surfactants to solubilize drugs of interest are also highlighted. This review will give an insight into the selection of drugs in different applications as their properties get modified by interaction with bile salts, thus influencing their solution behavior which, in turn, modifies the phase-forming behavior, microemulsion, and clouding phenomenon, besides solubilization. Finally, their future perspectives are taken into consideration to assess their possible uses as bio-surfactants without side effects to human beings.KeywordsBile saltsSurfactantsDrugsThermodynamicsPhysico-chemical propertiesInteractions