Reduction in choroidal thickness of macular area in polypoidal choroidal vasculopathy patients after intravitreal ranibizumab therapy

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• 作者：Tadayuki Nishide (1)
  Natsuki Hayakawa (1)
  Misako Nakanishi (1)
  Mai Ishii (1)
  Shinya Okazaki (1)
  Ikuko Kimura (1)
  Etsuko Shibuya (1)
  Nobuhisa Mizuki (1)
  
• 关键词：Choroidal thickness ; Polypoidal choroidal vasculopathy ; Enhanced depth imaging ; Optical coherence tomography ; Ranibizumab
• 刊名：Graefe's Archive for Clinical and Experimental Ophthalmology
• 出版年：2013
• 出版时间：October 2013
• 年：2013
• 卷：251
• 期：10
• 页码：2415-2420
• 全文大小：434KB
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  14. Hikichi T, Ohtsuka H, Higuchi M, Matsushita T, Ariga H, Kosaka S, Matsushita R, Takami K (2010) Improvement of angiographic findings of polypoidal choroidal vasculopathy after intravitreal injection of ranibizumab monthly for 3 months. Am J Ophthalmol 150(5):674鈥?82 CrossRef
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• 作者单位：Tadayuki Nishide (1)
  Natsuki Hayakawa (1)
  Misako Nakanishi (1)
  Mai Ishii (1)
  Shinya Okazaki (1)
  Ikuko Kimura (1)
  Etsuko Shibuya (1)
  Nobuhisa Mizuki (1)
  
  1. Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, 3-9, Fukuura, Kanazawa-ku, Yokohama-city, Kanagawa, Japan, 236-0004
  
• ISSN：1435-702X

文摘

Background To evaluate changes in retinal and choroidal thickness changes after three intravitreal ranibizumab (IVR) injections for polypoidal choroidal vasculopathy (PCV) using enhanced depth-imaging-optical coherence tomography (EDI-OCT). Methods In this retrospective, observational case series, EDI-OCT was used to measure changes in choroidal thickness at nine points in a lattice shape in the macula before and after introductory-stage IVR. Results Choroidal thickness was decreased at all nine points in the lattice shape, but was significantly decreased only at the fovea. Conclusion The subfoveal choroidal thickness may be reduced by introductory-stage IVR in patients with PCV. In particular, choroidal thickness at the fovea was reduced during the early stage of treatment.