Variation at NRG1 genotype related to modulation of small-world properties of the functional cortical network

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• 作者：Alba Lubeiro ; Javier Gomez-Pilar…
• 关键词：Imaging genetics ; Neuroimaging ; NRG1 ; Psychosis ; Small ; world
• 刊名：European Archives of Psychiatry and Clinical Neuroscience
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：267
• 期：1
• 页码：25-32
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Psychiatry; Neurosciences; Neurology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1433-8491
• 卷排序：267

文摘

Functional brain networks possess significant small-world (SW) properties. Genetic variation relevant to both inhibitory and excitatory transmission may contribute to modulate these properties. In healthy controls, genotypic variation in Neuregulin 1 (NRG1) related to the risk of psychosis (risk alleles) would contribute to functional SW modulation of the cortical network. Electroencephalographic activity during an odd-ball task was recorded in 144 healthy controls. Then, small-worldness (SWn) was calculated in five frequency bands (i.e., theta, alpha, beta1, beta2 and gamma) for baseline (from −300 to the stimulus onset) and response (150–450 ms post-target stimulus) windows. The SWn modulation was defined as the difference in SWn between both windows. Association between SWn modulation and carrying the risk allele for three single nucleotide polymorphisms (SNP) of NRG1 (i.e., rs6468119, rs6994992 and rs7005606) was assessed. A significant association between three SNPs of NRG1 and the SWn modulation was found, specifically: NRG1 rs6468119 in alpha and beta1 bands; NRG1 rs6994992 in theta band; and NRG1 rs7005606 in theta and beta1 bands. Genetic variation at NRG1 may influence functional brain connectivity through the modulation of SWn properties of the cortical network.