How Selected Tissues of Lactating Holstein Cows Respond to Dietary Polyunsaturated Fatty Acid Supplementation

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• 作者：Beate Hiller (1)
  Joaquin Angulo (2)
  Martha Olivera (2)
  Gerd Nuernberg (1)
  Karin Nuernberg (1)
  
• 关键词：Dairy cattle ; Lactation ; Lipid supplementation ; Tissue metabolism ; Lipid homeostasis
• 刊名：Lipids
• 出版年：2013
• 出版时间：April 2013
• 年：2013
• 卷：48
• 期：4
• 页码：357-367
• 全文大小：378KB
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• 作者单位：Beate Hiller (1)
  Joaquin Angulo (2)
  Martha Olivera (2)
  Gerd Nuernberg (1)
  Karin Nuernberg (1)
  
  1. Research Units Muscle Biology and Growth and Genetics and Biometry, Leibniz Institute for Farm Animal Biology, Wilhelm-Stahl-Allee 2, 18196, Dummerstorf, Germany
  2. Group Grica, Faculty of Agricultural Science, University of Antioquia, AA 1226, Medellín, Colombia
  
• ISSN：1558-9307

文摘

The effect of a 10-week supplementation with polyunsaturated fatty acids [via sunflower oil/DHA-rich algae (SUNA) or linseed oil/DHA-rich algae (LINA) enriched diets] versus saturated fatty acids (SAT) of lactating German Holstein dairy cows in mid-lactation on expression patterns of lipid metabolism-associated genes and gene products in hepatic, longissimus muscle and subcutaneous/perirenal/omental adipose tissue was assessed. Most pronounced transcriptomic responses to dietary PUFA were obtained in hepatic [down-regulated ACACA (FC?=?0.83, SUNA; FC?=?0.86, LINA), FADS1 (FC?=?0.60, SUNA; FC?=?0.72, LINA), FADS2 (FC?=?0.64, SUNA; FC?=?0.79, LINA), FASN (FC?=?0.64, SUNA; FC?=?0.72, LINA), SCD (FC?=?0.37, SUNA; FC?=?0.47, LINA) and SREBF1 (FC?=?0.79, SUNA, LINA) expression] and omental adipose [up-regulated ACACA (FC?=?1.58, SUNA; FC?=?1.22, LINA), ADFP (FC?=?1.33, SUNA; FC?=?1.32, LINA), CEBPA (FC?=?1.75, SUNA; FC?=?1.40, LINA), FASN (FC?=?1.57, SUNA; FC?=?1.21, LINA), LPL (FC?=?1.50, SUNA; FC?=?1.20, LINA), PPARG (FC?=?1.36, SUNA; FC?=?1.12, LINA), SCD (FC?=?1.41, SUNA; FC?=?1.17, LINA) and SREBF1 (FC?=?1.56, SUNA; FC?=?1.18, LINA) expression] tissue. Interestingly, gene/gene product associations were comparatively low in hepatic and omental adipose tissue compared with longissimus muscle, perirenal adipose and subcutaneous adipose tissue, indicating matches only in regard to minor concentrations of SCD product 18:1c9, FADS1 product 20:4n-6 and FADS2 product 18:3n-6 in hepatic tissue, and higher concentrations of ACACA and FASN gene products 12:0 and 14:0 and SCD product 18:2c9,t11 in omental adipose tissue. Whereas all analyzed tissues accumulated dietary PUFA and their ruminally generated biohydrogenation products, tissue-divergent preferences for certain fatty acids were identified. This descriptive study reports tissue-divergent effects of dietary PUFA and outlines the significance of a PUFA intervention with regard to dairy cows-nutritional management.