Spontaneous ischaemic stroke lesions in a dog brain: neuropathological characterisation and comparison to human ischaemic stroke
详细信息 查看全文
- 作者：Barbara Blicher Thomsen ; Hanne Gredal ; Martin Wirenfeldt…
- 关键词：Animal model ; Astrocyte ; Canine ; Cerebral infarction ; Cerebrovascular accident ; Infarct ; Microglia ; Middle cerebral artery occlusion
- 刊名：Acta Veterinaria Scandinavica
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：59
- 期：1
- 全文大小：2403KB
- 刊物主题：Veterinary Medicine/Veterinary Science; Animal Anatomy / Morphology / Histology;
- 出版者：BioMed Central
- ISSN：1751-0147
- 卷排序：59
文摘
BackgroundDogs develop spontaneous ischaemic stroke with a clinical picture closely resembling human ischaemic stroke patients. Animal stroke models have been developed, but it has proved difficult to translate results obtained from such models into successful therapeutic strategies in human stroke patients. In order to face this apparent translational gap within stroke research, dogs with ischaemic stroke constitute an opportunity to study the neuropathology of ischaemic stroke in an animal species.