A case of medulloblastoma in adult patient affected by anaplastic oligoastrocytoma

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• 作者：G. Simonetti ; Paola Gaviani ; E. Lamperti ; A. Innocenti ; A. Botturi…
• 关键词：Medulloblastoma ; High ; grade glioma ; Radiotherapy ; induced tumors ; Genetic abnormalities
• 刊名：Neurological Sciences
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：37
• 期：10
• 页码：1727-1730
• 全文大小：622 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Neurology
  Neuroradiology
  Neurosurgery
  Psychiatry
  
• 出版者：Springer Milan
• ISSN：1590-3478
• 卷排序：37

文摘

Medulloblastomas and high-grade gliomas (HGG) are two distinct brain tumor, with different peculiarities in terms of age of onset, localizations and prognosis. The coexistence of the two neoplasms in the same adult patient is an extremely rare event. We present the case of a woman treated with radio-chemotherapy for an HGG, who developed a cerebellar medulloblastoma 7 years later. Considering the poor prognosis of these tumors, the lack of knowledge about the mechanisms of onset as well as effective therapies, it is necessary to determine the exact role of irradiation and the presence of any potential molecular genetic abnormalities in the developing of the two tumors.