Superior temporal gyrus thickness correlates with cognitive performance in multiple sclerosis

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• 作者：Asaf Achiron (1)
  Joab Chapman (1)
  Sigal Tal (2)
  Eran Bercovich (3)
  Hararai Gil (3)
  Anat Achiron (3)
  
• 关键词：Multiple sclerosis ; Cortical thickness ; MRI ; Cognitive performance ; Superior temporal gyrus
• 刊名：Brain Structure and Function
• 出版年：2013
• 出版时间：July 2013
• 年：2013
• 卷：218
• 期：4
• 页码：943-950
• 全文大小：543KB
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• 作者单位：Asaf Achiron (1)
  Joab Chapman (1)
  Sigal Tal (2)
  Eran Bercovich (3)
  Hararai Gil (3)
  Anat Achiron (3)
  
  1. Department of Neurology, Multiple Sclerosis Center, Sheba Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Hashomer, Israel
  2. Department of Radiology, Sheba Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Hashomer, Israel
  3. Multiple Sclerosis Center, Sheba Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Hashomer, Israel
  

文摘

Decreased cortical thickness that signifies gray matter pathology and its impact on cognitive performance is a research field with growing interest in relapsing–remitting multiple sclerosis (RRMS) and needs to be further elucidated. Using high-field 3.0?T MRI, three-dimensional T1-FSPGR (voxel size 1?×?1?×?1?mm) cortical thickness was measured in 82 regions in the left hemisphere (LH) and right hemisphere (RH) in 20 RRMS patients with low disease activity and in 20 age-matched healthy subjects that in parallel underwent comprehensive cognitive evaluation. The correlation between local cortical atrophy and cognitive performance was examined. We identified seven regions with cortical tissue loss that differed between RRMS and age-matched healthy controls. These regions were mainly located in the frontal and temporal lobes, specifically within the gyrus rectus, inferior frontal sulcus, orbital gyrus, parahippocampal gyrus, and superior temporal gyrus, with preferential left asymmetry. Increased cortical thickness was identified in two visual sensory regions, the LH inferior occipital gyrus, and the RH cuneus, implicating adaptive plasticity. Correlation analysis demonstrated that only the LH superior temporal gyrus thickness was associated with cognitive performance and its thickness correlated with motor skills (r?=?0.65, p?=?0.003), attention (r?=?0.45, p?=?0.042), and information processing speed (r?=?0.50, p?=?0.025). Our findings show that restricted cortical thinning occurs in RRMS patients with mild disease and that LH superior temporal gyrus atrophy is associated with cognitive dysfunction.