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A phase I study of prolonged infusion of triapine in combination with fixed dose rate gemcitabine in patients with advanced solid tumors
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  • 作者:Amir Mortazavi (1)
    Yonghua Ling (2)
    Ludmila Katherine Martin (1)
    Lai Wei (3)
    Mitch A. Phelps (2) (4)
    Zhongfa Liu (2) (4)
    Erica J. Harper (1)
    S. Percy Ivy (5)
    Xin Wu (1)
    Bing-Sen Zhou (6)
    Xiyong Liu (6)
    Deidre Deam (1)
    J. Paul Monk (1)
    William J. Hicks (1)
    Yun Yen (6)
    Gregory A. Otterson (1)
    Michael R. Grever (7)
    Tanios Bekaii-Saab (1)
  • 关键词:Triapine ; Gemcitabine ; Phase I ; Clinical Trial
  • 刊名:Investigational New Drugs
  • 出版年:2013
  • 出版时间:June 2013
  • 年:2013
  • 卷:31
  • 期:3
  • 页码:685-695
  • 全文大小:240KB
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    29. Feun L et al (2002) Phase I and pharmacokinetic study of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) using a single intravenous dose schedule. Cancer Chemother Pharmacol 50(3):223鈥?29 CrossRef
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    31. Wadler S et al (2004) Phase I and pharmacokinetic study of the ribonucleotide reductase inhibitor, 3-aminopyridine-2-carboxaldehyde thiosemicarbazone, administered by 96-hour intravenous continuous infusion. J Clin Oncol 22(9):1553鈥?563 CrossRef
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    39. Lopes G et al (2007) Oxaliplatin and fixed-rate infusional gemcitabine in the second-line treatment of patients with metastatic colon cancer: Final results of a phase II trial prematurely closed as a result of poor accrual. Clin Colorectal Cancer 6(9):641鈥?45 CrossRef
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    41. Nutting CM et al (2009) Phase II study of 3-AP Triapine in patients with recurrent or metastatic head and neck squamous cell carcinoma. Ann Oncol 20(7):1275鈥?279 CrossRef
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    44. Ma B et al (2008) A multicenter phase II trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, Triapine) and gemcitabine in advanced non-small-cell lung cancer with pharmacokinetic evaluation using peripheral blood mononuclear cells. Invest New Drugs 26(2):169鈥?73 CrossRef
    45. Ocean AJ et al (2011) Phase II trial of the ribonucleotide reductase inhibitor 3-aminopyridine-2-carboxaldehydethiosemicarbazone plus gemcitabine in patients with advanced biliary tract cancer. Cancer Chemother Pharmacol 68(2):379鈥?88 CrossRef
    46. Giles FJ et al (2003) Phase I and pharmacodynamic study of Triapine, a novel ribonucleotide reductase inhibitor, in patients with advanced leukemia. Leuk Res 27(12):1077鈥?083 CrossRef
    47. Kolesar J et al (2011) Population pharmacokinetics of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (Triapine(R)) in cancer patients. Cancer Chemother Pharmacol 67(2):393鈥?00 CrossRef
  • 作者单位:Amir Mortazavi (1)
    Yonghua Ling (2)
    Ludmila Katherine Martin (1)
    Lai Wei (3)
    Mitch A. Phelps (2) (4)
    Zhongfa Liu (2) (4)
    Erica J. Harper (1)
    S. Percy Ivy (5)
    Xin Wu (1)
    Bing-Sen Zhou (6)
    Xiyong Liu (6)
    Deidre Deam (1)
    J. Paul Monk (1)
    William J. Hicks (1)
    Yun Yen (6)
    Gregory A. Otterson (1)
    Michael R. Grever (7)
    Tanios Bekaii-Saab (1)

    1. Division of Medical Oncology, Department of Internal Medicine, College of Medicine, The Ohio State University and The Comprehensive Cancer Center, A454 Starling-Loving Hall, 320 West 10th Ave, Columbus, OH, 43210, USA
    2. Pharmacoanalytical Shared Resources, The Ohio State University and The Comprehensive Cancer Center, Columbus, OH, 43210, USA
    3. Center for Biostatistics, The Ohio State University and The Comprehensive Cancer Center, Columbus, OH, 43210, USA
    4. Division of Pharmaceutics, College of Pharmacy, The Ohio State University and The Comprehensive Cancer Center, Columbus, OH, 43210, USA
    5. Cancer Therapeutics Evaluation Program, National Cancer Institute, Rockville, MD, 20852, USA
    6. City of Hope Comprehensive Cancer Center, Duarte, CA, 91010, USA
    7. Division of Hematology, Department of Internal Medicine, The Ohio State University and The Comprehensive Cancer Center, Columbus, OH, 43210, USA
  • ISSN:1573-0646
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