Matrix Metalloproteinase-9 and the Cu/Zn Ratio as Ancillary Diagnostic Tools in Distinguishing Between the Classical and Follicular Variants of Papillary Thyroid Carcinoma
详细信息 查看全文
- 作者：Vesna V. Dragutinovi? (1)
Svetislav B. Tati? (2)
Sne?ana Nikoli?-Mandi? (3)
Svetlana Savin (4)
Dubravka Cveji? (4)
Du?ko Dun?erovi? (2)
Milan Gaji? (5)
Ivan Paunovi? (6) (7) - 关键词：Papillary thyroid carcinoma ; Matrix metalloproteinase ; 9 ; Trace elements (Cu and Zn) ; Immunohistochemistry
- 刊名：Biological Trace Element Research
- 出版年：2012
- 出版时间：October 2012
- 年：2012
- 卷：149
- 期：1
- 页码：29-33
- 全文大小：202KB
- 参考文献：1. Al-Brahim N, Asa SL (2006) Papillary thyroid carcinoma: an overview. Arch Pathol Lab Med 130:1057-062
2. Liu J, Singh B, Tallini G, Carlson DL, Katabi N, Shaha A, Tuttle RM, Ghossein RA (2006) Follicular variant of papillary thyroid carcinoma: a clinicopathologic study of problematic entity. Cancer 107(6):1255-264 CrossRef
3. Lang BH, Lo CY, Chan WF, Lam AK, Wan KY (2006) Classical and follicular variant of papillary thyroid carcinoma: a comparative study on clinicopatholgic features and long-term outcome. World J Surg 30(5):752-58 CrossRef
4. Passler C, Prager G, Scheuba C, Niederle BE, Kaserer K, Zettinig G, Niederle B (2003) Follicular variant of papillary thyroid carcinoma: a long-term follow-up. Arch Surg 138(12):1362-366 CrossRef
5. Sebastian SO, Gonzales JM, Paricio PP, Perez JS, Flores DP, Madrona AP, Romero PR, Tebar FJ (2000) Papillary thyroid carcinoma: prognostic index for survival including the histological variety. Arch Surg 135(3):272-77 CrossRef
6. Lloyd RV, Erickson LA, Casey MB, Lam KY, Lohse CM, Asa SL, Chan JK, DeLellis RA, Harach HR, Kakudo K, LiVolsi VA, Rosai J, Sebo TJ, Sobrinho-Simoes M, Wenig BM, Lae ME (2004) Observer variation in the diagnosis of follicular variant of papillary thyroid carcinoma. Am J Surg Pathol 28(10):1336-340 CrossRef
7. Liotta LA (1986) Tumor invasion and metastases: role of the extracellular matrix: Rhoads memorial award lecture. Cancer Res 46:1- CrossRef
8. Liotta LA, Tryggvason K, Garbis S, Hart I, Foltz CM, Shafie S (1980) Metastatic potential correlates with enzymatic degradation of basement membrane collagen. Nature 284:67-8 CrossRef
9. Mc Cawley LJ, Matrisian LM (2000) Matrix metalloproteinases: multifunctional contributors to tumor progression. Mol Med Today 6(4):149-56 CrossRef
10. Yucel I, Arpaci F, Ozet A, Doner B, Karayilanoglu T, Sayar A, Berk O (1994) Serum copper and zinc levels and copper/zinc ration in patients with breast cancer. Biol Trace Element Res 40:31-8 CrossRef
11. Kokosoy C, Kavas GO, Akcil E, Kocaturk PA, Kara S, Ozarslan C (1997) Trace elements and superoxide dismutase in benign and malignant breast disease. Breast Cancer Res Treat 45:1- CrossRef
12. Sobin LH, Wittekind CH (1997) TNM classification of malignant tumours. Wiley-Liss, New York
13. Beesley MF, McLaren KM (2002) Cytokeratin 19 and galectin-3 immunohistochemistry in the differential diagnosis of solitary thyroid nodules. Histopathology 41(3):236-43 CrossRef
14. Volante M, Bozzalla-Casione F, DePompa R, Saggiorato E, Bartolazzi A, Orlandi F, Papotti M (2004) Galectin-3 and HBME-1 expression in oncocytic cell tumors of the thyroid. Virchows Arch 445(2):183-88 CrossRef
15. Nasir A, Catalano E, Calafati S, Cantor A, Kaiser HE, Coppola D (2004) Role of p53, CD44V6 and CD57 in differentiating between bening and malignant follicular neoplasms of the thyroid. Vivo 18(2):189-95
16. Tomoda C, Kushima R, Takeuti E, Mukaisho K, Hattori T, Kitano H (2003) CD10 expession is useful in the diagnosis of follicular carcinoma and follicular variant of papillary thyroid carcinoma. Thyroid 13(3):291-95 CrossRef
17. Yegen G, Demir MA, Ertan Y, Nalbant OA, Tuncyurek M (2009) Can CD10 be used as a diagnostic marker in thyroid pathology. Virchows Arch 454:101-05 CrossRef
18. Baldini E, Toller M, Graziano FM, Russo FP, Pepe M, Biordi L, Marchioni E, Curcio F, Ulisse S, Ambesi-Impiombato FS, D'Armiento M (2004) Expession of matrix metalloproteinases and their specific inhibitors in normal and different human thyroid tumor cell lines. Thyroid 14:881-88 CrossRef
19. Maeta H, Oghi S, Terada T (2001) Protein expression of matrix metalloproteinases 2 and 9 and tissue inhibitors of metalloproteinase 1 and 2 in papillary thyroid carcinomas. Virchows Arch 438:121-28 CrossRef
20. Thian X, Cong M, Zhou W, Zhu J, Lui Q (2008) Relationship between protein expression of VEGF-C, MMP-2 and lymph node metastases in papillary thyroid cancer. J Int Med Res 36:699-03
21. Kraiem Z, Korem S (2000) Matrix metalloproteinases and the thyroid. Thyroid 10:1061-069 CrossRef
22. Nakamura H, Ueno H, Yamashita K, Shimada T, Yamamoto E, Noguchi M, Fujimoto N, Sato H, Seiki M, Okada Y (1999) Enhanced production and activation of progelatinase A by membrane type 1 matrix metalloproteinase in human papillary thyroid carcinomas. Cancer Res 59:467-73
23. Garg AN, Singh V, Weginwar RG, Sagdeo VN (1994) An elemental correlation study in cancerous and normal breast tissue with successive clinical stages by neutron activation analysis. Biol Trace Element Res 46:185-02 CrossRef
24. Ng KH, Bradley LLM, Mahmood CS, Wood AK (1993) Differentiation of elemental composition of normal and malignant breast tissue by instrumental neutron activation analysis. Appl Radiat Isot 44:511-16 CrossRef
25. Gerber M, Richardson S, Salkeld R, Chappuis P (1991) Antioxidants in female breast cancer patients. Cancer Invest 91:421-28 CrossRef
26. Cavallo F, Gerber M, Marrubini E (1991) Zink and copper in breast cancer. Cancer 67:738-45 CrossRef
27. Zoboli A (1996) A case control study on selenium, zinc and copper in plasma and hair of subjects affected by breast and lung cancer. Biol Trace Element Res 51:23-0 CrossRef
28. Kucharzewski M, Braziewicz J, Majewska U, Gozdz S (2003) Copper, zinc and selenium in whole blood and thyroid tissue of people with various thyroid diseases. Biol Trace Element Res 93:9-8 CrossRef - 作者单位：Vesna V. Dragutinovi? (1)
Svetislav B. Tati? (2)
Sne?ana Nikoli?-Mandi? (3)
Svetlana Savin (4)
Dubravka Cveji? (4)
Du?ko Dun?erovi? (2)
Milan Gaji? (5)
Ivan Paunovi? (6) (7)
1. Institute of Medical Chemistry, Faculty of Medicine, University of Belgrade, Belgrade, Serbia
2. Institute of Pathology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia
3. Faculty of Chemistry, University of Belgrade, Belgrade, Serbia
4. Institute for the Application of Nuclear Energy–INEP, University of Belgrade, Belgrade, Serbia
5. Institute for Medical Statistics and Informatics, Faculty of Medicine, University of Belgrade, Belgrade, Serbia
6. Center for Endocrine Surgery, Clinic for Endocrinology, Diabetes and Diseases of Metabolism, Clinical Center of Serbia, Belgrade, Serbia
7. Faculty of Medicine, University of Belgrade, Belgrade, Serbia
文摘
The most common histological variants of papillary thyroid carcinoma (PTC), classical (CPTC) and follicular (FPTC), have different diagnostic features, molecular biology, and prognosis. Matrix metalloproteinase-9 (MMP-9) endopeptidase which degrades the components of the extracellular matrix is essential in the invasive growth and metastasizing of malignant tumors. The serum copper (Cu)/zinc (Zn) ratios are sensitive diagnostic and prognostic indicators in oncology since Cu- and Zn-dependent enzymes play important roles in the genesis and the progression of tumors. The aim of this study was to examine the expressions of MMP-9 in tissues of CPTC and FPTC, as well as to determine the Cu/Zn ratios in the same samples. MMP-9 was determined immunohistochemically, and the concentrations of copper and zinc in thyroid tissue were determined by means of flame atomic absorption spectrometry. The results obtained revealed significantly higher expressions of MMP-9 in CPTC in comparison with FPTC, as well as higher Cu/Zn ratios in CPTC than in FPTC. Thus, determining MMP-9 activities and the Cu/Zn ratios could improve the accuracy of the standard histopathological diagnosis of these two types of PTC.