α-PVP (“flakka”): a new synthetic cathinone invades the drug arena
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- 作者：Maria Katselou ; Ioannis Papoutsis ; Panagiota Nikolaou…
- 关键词：Flakka ; α ; PVP ; Synthetic cathinone ; Pharmacology ; Toxicology ; Legal status
- 刊名：Forensic Toxicology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：34
- 期：1
- 页码：41-50
- 全文大小：508 KB
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Ioannis Papoutsis (1)
Panagiota Nikolaou (1)
Chara Spiliopoulou (1)
Sotiris Athanaselis (1)
1. Department of Forensic Medicine and Toxicology, Faculty of Medicine, National and Kapodistrian University of Athens, 75 Mikras Asias, 115 27, Athens, Greece - 刊物主题：Forensic Medicine; Pharmacology/Toxicology; Medicinal Chemistry; Medicine/Public Health, general; Medical Law;
- 出版者：Springer Japan
- ISSN：1860-8973
文摘
“Flakka” is the street name for the synthetic cathinone α-pyrrolidinopentiophenone (α-PVP). Although it was developed by Boehringer Ingelheim as a central nervous system stimulant and pressor agent in the 1960s, it entered in the drug arena at an accelerated rate during the last 4 years causing intoxications, fatal or not. α-PVP is abused in Europe, as well as in the United States and Japan, as a substituent of 3, 4-methylenedioxypyrovalerone, and recently scheduled by the United States Drug Enforcement Administration, possessing similar pharmacological action to that of the latter. It can be easily manufactured and purchased through the Internet or in retail shops and is usually sold as “bath salts”. The aim of this review is to summarize the current knowledge of this drug concerning its chemistry, synthesis, metabolism, pharmacology, and toxicology. “Flakka” related cases, published or reported, including fatalities or intoxications, as well as seizures are reviewed. The existing analytical methodologies for the determination of α-PVP in biological and postmortem samples are summarized, and its current legal status is reported. Keywords Flakka α-PVP Synthetic cathinone Pharmacology Toxicology Legal status