Herpes simplex virus 2 infection: molecular association with HIV and novel microbicides to prevent disease

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• 作者：Paula A. Suazo ; Eduardo I. Tognarelli…
• 关键词：Clinical manifestations ; Pathology ; Epidemiology ; Co ; infection ; Therapeutic and prophylactic antivirals ; Antiviral resistance
• 刊名：Medical Microbiology and Immunology
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：204
• 期：2
• 页码：161-176
• 全文大小：537 KB
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• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Medical Microbiology
  Immunology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1831

文摘

Infection with herpes simplex viruses is one of the most ancient diseases described to affect humans. Infection with these viruses produces vexing effects to the host, which frequently recur. Infection with herpes simplex viruses is lifelong, and currently there is no vaccine or drug to prevent or cure infection. Prevalence of herpes simplex virus 2 (HSV-2) infection varies significantly depending on the geographical region and nears 20?% worldwide. Importantly, HSV-2 is the first cause of genital ulcers in the planet. HSV-2 affects approximately 500 million people around the globe and significantly increases the likelihood of acquiring the human immunodeficiency virus (HIV), as well as its shedding. Thus, controlling HSV-2 infection and spread is of public health concern. Here, we review the diseases produced by herpes simplex viruses, the factors that modulate HSV-2 infection, the relationship between HSV-2 and HIV and novel therapeutic and prophylactic microbicides/antivirals under development to prevent infection and pathological outcomes produced by this virus. We also review mutations associated with HSV-2 resistance to common antivirals.