Survival of children with medulloblastoma in Canada diagnosed between 1990 and 2009 inclusive

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• 作者：Donna L. Johnston ; Daniel Keene ; Maria Kostova…
• 关键词：Medulloblastoma ; Survival ; Pediatric
• 刊名：Journal of Neuro-Oncology
• 出版年：2015
• 出版时间：September 2015
• 年：2015
• 卷：124
• 期：2
• 页码：247-253
• 全文大小：494 KB
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• 作者单位：Donna L. Johnston (1)
  Daniel Keene (2)
  Maria Kostova (1)
  Lucie Lafay-Cousin (3)
  Chris Fryer (4)
  Katrin Scheinemann (5)
  Anne-Sophie Carret (6)
  Adam Fleming (7)
  Vanessa Percy (8)
  Samina Afzal (9)
  Beverly Wilson (10)
  Lynette Bowes (11)
  Shayna Zelcer (12)
  Chris Mpofu (13)
  Mariana Silva (14)
  Valerie Larouche (15)
  Josee Brossard (16)
  Douglas Strother (3)
  Eric Bouffet (17)
  
  1. Division of Pediatric Hematology/Oncology, Children’s Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, ON, K1H 8L1, Canada
  2. Division of Pediatric Neurology, Children’s Hospital of Eastern Ontario, Ottawa, ON, Canada
  3. Section of Pediatric Oncology and Blood and Marrow Transplantation, University of Calgary, Calgary, AB, Canada
  4. Division of Pediatric Hematology/Oncology, British Columbia Children’s Hospital, Vancouver, BC, Canada
  5. Division of Pediatric Hematology/Oncology, McMaster Children’s Hospital, Hamilton, ON, Canada
  6. Division of Pediatric Hematology/Oncology, St Justine Hospital, Montreal, QC, Canada
  7. Division of Pediatric Hematology/Oncology, Montreal Children’s Hospital, Montreal, QC, Canada
  8. Division of Pediatrics, CancerCare Manitoba, Winnipeg, MB, Canada
  9. Division of Pediatric Hematology/Oncology, IWK Children’s Hospital, Halifax, NS, Canada
  10. Division of Pediatric Hematology/Oncology, Stollery Children’s Hospital, Edmonton, AB, Canada
  11. Division of Pediatric Hematology/Oncology, Janeway Children’s Hospital, St John’s, NL, Canada
  12. Division of Pediatric Hematology/Oncology, Children’s Hospital of Western Ontario, London, ON, Canada
  13. Division of Pediatric Hematology/Oncology, Saskatoon Children’s Hospital, Saskatoon, SK, Canada
  14. Division of Pediatric Hematology/Oncology, Kingston General Hospital, Kingston, ON, Canada
  15. Division of Pediatric Hematology/Oncology, Centre Hospitalier Universitaire de Quebec, Quebec City, QC, Canada
  16. Division of Pediatric Hematology/Oncology, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada
  17. Division of Pediatric Hematology/Oncology, Hospital for Sick Children, Toronto, ON, Canada
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Oncology
  
• 出版者：Springer Netherlands
• ISSN：1573-7373

文摘

The treatment of medulloblastoma, the most common malignant brain tumor in children, has evolved over the last few decades. The objectives of this paper were to determine the survival of pediatric medulloblastoma in Canada, to determine if there has been an improvement in the survival rates between the years of 1990 and 2009, inclusive, and to determine prognostic factors for survival. All patients under the age of 18 years diagnosed with medulloblastoma from 1990 to 2009, inclusive, in Canada were included. Data collected included date of diagnosis, age at diagnosis, gender, stage, pathology, treatment, recurrence and current status. From these, survival rates were determined. Data were obtained on 628 eligible patients. The overall 5-year survival rate for the study time period was 69.2 ± 3.3 %. The survival rate increased during the interval of 1996-000, then remained stable; 1990-994: 60.2 ± 4.3 %; 1995-999: 73.2 ± 3.5 %; 2000-004: 68.8 ± 3.7 %; and 2005-009: 72.1 ± 4.9 %, p = 0.05. Children over 14 years of age had a significantly better overall survival than those age 5-4 and those under 5 (85.7 ± 5.5 % vs 76.1 ± 2.7 % and 60.8 ± 3 % respectively, p = 0.001). Histologic medulloblastoma subtype and M stage of disease did not result in significant differences in survival. Despite changes in approaches to therapy, we demonstrate a steady survival rate for children with medulloblastoma after 1996. In our analyses, age over 14 years was associated with a higher survival rate. Keywords Medulloblastoma Survival Pediatric