High rates of obesity and greater associated disability among people with rheumatoid arthritis in Canada

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• 作者：Inés Colmegna ; Carol A. Hitchon ; María Celia Bazán Bardales…
• 关键词：Cardiovascular disease risk ; Disability ; Obesity ; Rheumatoid arthritis
• 刊名：Clinical Rheumatology
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：35
• 期：2
• 页码：457-460
• 全文大小：260 KB
• 参考文献：1.McCoy SS, Crowson CS, Maradit-Kremers H et al (2013) Longterm outcomes and treatment after myocardial infarction in patients with rheumatoid arthritis. J Rheumatol 40:605–10PubMedCentral CrossRef PubMed
  2.Crowson CS, Liao KP, Davis JM 3rd et al (2013) Rheumatoid arthritis and cardiovascular disease. Am Heart J 166(622–8):e1PubMed
  3.Armstrong DJ, McCausland EM, Quinn AD, Wright GD (2006) Obesity and cardiovascular risk factors in rheumatoid arthritis. Rheumatology (Oxford) 45:782, author reply −3CrossRef
  4.Vidal C, Barnetche T, Morel J, Combe B, Daien C (2015) Association of body mass index categories with disease activity and radiographic joint damage in rheumatoid arthritis: a systematic review and metaanalysis. J Rheumatol 42:2261–9CrossRef PubMed
  5.Sandberg ME, Bengtsson C, Kallberg H et al (2014) Overweight decreases the chance of achieving good response and low disease activity in early rheumatoid arthritis. Ann Rheum Dis 73:2029–33CrossRef PubMed
  6.Keys A, Fidanza F, Karvonen MJ, Kimura N, Taylor HL (2014) Indices of relative weight and obesity. Int J Epidemiol 43:655–65CrossRef PubMed
  7.Adams KF, Schatzkin A, Harris TB et al (2006) Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old. N Engl J Med 355:763–78CrossRef PubMed
  8.Stavropoulos-Kalinoglou A, Metsios GS, Koutedakis Y et al (2007) Redefining overweight and obesity in rheumatoid arthritis patients. Ann Rheum Dis 66:1316–21PubMedCentral CrossRef PubMed
  9.Katz PP, Yazdany J, Trupin L et al (2013) Sex differences in assessment of obesity in rheumatoid arthritis. Arthritis Care Res 65:62–70CrossRef
  10. https://​secure.​cihi.​ca/​free_​products/​Obesity_​in_​canada_​2011_​en.​pdf . Obesity in canada. A joint report from the public health agency of canada and the canadian institute for health information.
  11.Giles JT, Ling SM, Ferrucci L et al (2008) Abnormal body composition phenotypes in older rheumatoid arthritis patients: association with disease characteristics and pharmacotherapies. Arthritis Rheum 59:807–15PubMedCentral CrossRef PubMed
  12.Humphreys JH, Verstappen SM, Mirjafari H et al (2013) Association of morbid obesity with disability in early inflammatory polyarthritis: results from the norfolk arthritis register. Arthritis Care Res 65:122–6CrossRef
  13.Somers TJ, Wren AA, Blumenthal JA, Caldwell D, Huffman KM, Keefe FJ (2014) Pain, physical functioning, and overeating in obese rheumatoid arthritis patients: do thoughts about pain and eating matter? J Clin Rheumatol 20:244–50PubMed
  14.Jawaheer D, Olsen J, Lahiff M et al (2010) Gender, body mass index and rheumatoid arthritis disease activity: results from the quest-ra study. Clin Exp Rheumatol 28:454–61PubMedCentral PubMed
  15.Giles JT, Bartlett SJ, Andersen R, Thompson R, Fontaine KR, Bathon JM (2008) Association of body fat with c-reactive protein in rheumatoid arthritis. Arthritis Rheum 58:2632–41PubMedCentral CrossRef PubMed
  16.Uutela T, Kautiainen H, Jarvenpaa S, Salomaa S, Hakala M, Hakkinen A (2014) Waist circumference based abdominal obesity may be helpful as a marker for unmet needs in patients with RA. Scand J Rheumatol 43:279–85CrossRef PubMed
  17.Heo M, Allison DB, Faith MS, Zhu S, Fontaine KR (2003) Obesity and quality of life: mediating effects of pain and comorbidities. Obes Res 11:209–16CrossRef PubMed
  
• 作者单位：Inés Colmegna (1) (4)
  Carol A. Hitchon (3)
  María Celia Bazán Bardales (1)
  Lekha Puri (1)
  Susan J. Bartlett (1) (2)
  
  1. Division of Rheumatology, Department of Medicine, McGill University, 687 Pine Avenue, room E287, Montreal, QC, H3A 1A1, Canada
  4. Royal Victoria Hospital, Research Institute of the McGill University Health Centre, 1001 Décarie Blvd, Bloc E, M2-3238, Montréal, QC, H4A 3J1, Canada
  3. Division of Rheumatology, Department of Medicine, University of Manitoba, 66 Chancellors Cir, Winnipeg, MB, R3T 2N2, Canada
  2. Division of Clinical Epidemiology, Department of Medicine, McGill University, 687 Pine Avenue, room E287, Montreal, QC, H3A 1A1, Canada
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Rheumatology
  
• 出版者：Springer London
• ISSN：1434-9949

文摘

Obesity in rheumatoid arthritis has been associated with increased risk of comorbidities, larger medical costs, decreased quality of life, higher disease activity, and reduced therapeutic responses. We assessed the burden of obesity among rheumatoid arthritis patients and its impact on patient-reported outcomes. Patients receiving care at two Canadian University Centers were included. Height and weight were measured and selected sociodemographic and rheumatoid arthritis (RA) characteristics as well as patient-reported outcomes were obtained. Patients were classified according to WHO criteria and proposed RA cut points, and results were compared with national data. Using WHO criteria, 68 (34 %) RA patients were classified as obese (vs. ~25 % of Canadians). Using RA cut points, 112 (55 %) RA patients were classified as obese. With both classification methods, obese individuals had significantly higher mean HAQ scores and a higher odds of significant disability (HAQ ≥ 1: WHO OR 2.3; 95 % CI 1.2, 4.2 and RA-specific OR 1.8; 95 % CI 1.0, 3.2). Independent of the classification method use, RA patients have significantly higher rates of obesity than national prevalence estimates. Obese RA patients had about twice the odds of reporting moderate to severe disability. Keywords Cardiovascular disease risk Disability Obesity Rheumatoid arthritis