Prolonged fibroblast growth factor 19 response in patients with primary sclerosing cholangitis after an oral chenodeoxycholic acid challenge
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- 作者：Serge J. Zweers ; Elisabeth M. de Vries ; Martin Lenicek…
- 关键词：Primary sclerosing cholangitis ; Chenodeoxycholic acid ; Fibroblast growth factor 19 ; Farnesoid X receptor
- 刊名：Hepatology International
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：11
- 期：1
- 页码：132-140
- 全文大小：743KB
- 刊物主题：Hepatology; Colorectal Surgery; Surgery;
- 出版者：Springer India
- ISSN：1936-0541
- 卷排序：11
文摘
BackgroundBile salts likely contribute to liver injury in patients with primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC). Fibroblast growth factor 19 (FGF19) is a bile salt-induced enterokine with hepatoprotective potential as it suppresses de novo bile salt synthesis. Here, we evaluated the bile salt receptor FXR/FGF19 gut–liver axis in PSC and PBC patients.