A Pediatric Bone Mass Scan has Poor Ability to Predict Peak Bone Mass: An 11-Year Prospective Study in 121 Children

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• 作者：Christian Buttazzoni ; Bjorn E. Rosengren…
• 关键词：Adult ; BMD ; BMC ; Bone mass ; Child ; Growth ; Peak bone mass
• 刊名：Calcified Tissue International
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：96
• 期：5
• 页码：379-388
• 全文大小：3,268 KB
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• 作者单位：Christian Buttazzoni (1)
  Bjorn E. Rosengren (1)
  Caroline Karlsson (1)
  Magnus Dencker (1)
  Jan-?ke Nilsson (1)
  Magnus K. Karlsson (1)
  
  1. Clinical and Molecular Osteoporosis Research Unit, Department of Orthopedics and Clinical Sciences, Sk?ne University Hospital, Lund University, 205 02, Malmō, Sweden
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Biochemistry
  Endocrinology
  Orthopedics
  Cell Biology
  
• 出版者：Springer New York
• ISSN：1432-0827

文摘

This 11-year prospective longitudinal study examined how a pre-pubertal pediatric bone mass scan predicts peak bone mass. We measured bone mineral content (BMC; g), bone mineral density (BMD; g/cm2), and bone area (cm2) in femoral neck, total body and lumbar spine by dual-energy X-ray absorptiometry in a population-based cohort including 65 boys and 56 girls. At baseline all participants were pre-pubertal with a mean age of 8?years (range 6-), they were re-measured at a mean 11?years (range 10-2) later. The participants were then mean 19?years (range 18-9), an age range that corresponds to peak bone mass in femoral neck in our population. We calculated individual BMC, BMD, and bone size Z scores, using all participants at each measurement as reference and evaluated correlations between the two measurements. Individual Z scores were also stratified in quartiles to register movements between quartiles from pre-pubertal age to peak bone mass. The correlation coefficients (r) between pre-pubertal and young adulthood measurements for femoral neck BMC, BMD, and bone area varied between 0.37 and 0.65. The reached BMC value at age 8?years explained 42?% of the variance in the BMC peak value; the corresponding values for BMD were 31?% and bone area 14?%. Among the participants with femoral neck BMD in the lowest childhood quartile, 52?% had left this quartile at peak bone mass. A pediatric bone scan with a femoral neck BMD value in the lowest quartile had a sensitivity of 47?% [95?% confidence interval (CI) 28, 66] and a specificity of 82?% (95?% CI 72, 89) to identify individuals who would remain in the lowest quartile at peak bone mass. The pre-pubertal femoral neck BMD explained only 31?% of the variance in femoral neck peak bone mass. A pre-pubertal BMD scan in a population-based sample has poor ability to predict individuals who are at risk of low peak bone mass.