Modification of polyfluorene nanoparticles via inclusion complexation based on cyclodextrin for lectin sensing and cell imaging

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• 作者：Pengfei Sun ; Mingchang Lin ; Guosong Chen ; Ming Jiang
• 关键词：inclusion complexation ; conjugated polymer nanoparticles ; polyfluorene ; glycopolymer ; Galectin ; 3
• 刊名：Science China Chemistry
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：59
• 期：12
• 页码：1616-1620
• 全文大小：
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry/Food Science, general;
• 出版者：Science China Press
• ISSN：1869-1870
• 卷排序：59

文摘

Currently, conjugated polymer nanoparticles are widely used with many biological applications, especially bio-imaging and labeling. Thus their modification with different biomacromolecules becomes a crucial step before various applications. In literature, this modification was normally performed via covalent bonds. To our best knowledge, modification based on inclusion complexation has not been reported. Herein, via host-guest interaction between cyclodextrin and adamantane, supramolecular modification to conjugated polyfluorene nanoparticles has been successfully achieved. The glycopolymer-modified conjugated polymer nanoparticles showed excellent binding ability to lectins, such as Galectin-3 and selective imaging behavior to Hep G2 cells.