Comparison of Ga-68-Labeled Fusarinine C-Based Multivalent RGD Conjugates and [⁶⁸Ga]NODAGA-RGD—In Vivo Imaging Studies in Human Xenograft Tumors

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• 作者：Chuangyan Zhai ; Gerben M. Franssen ; Milos Petrik…
• 关键词：Key wordsFusarinine C ; Integrins ; RGD peptides ; Gallium ; 68 ; Positron emission tomography (PET)
• 刊名：Molecular Imaging and Biology
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：18
• 期：5
• 页码：758-767
• 全文大小：3,205 KB
• 刊物主题：Imaging / Radiology;
• 出版者：Springer US
• ISSN：1860-2002
• 卷排序：18

文摘

PurposeMultimeric arginine-glycine-aspartic acid (RGD) peptides have advantages for imaging integrin α_vβ₃ expression. Here, we compared the in vitro and in vivo behavior of three different Ga-68-labeled multimeric Fusarinine C-RGD (FSC-RGD) conjugates, whereby RGD was coupled directly, via a succinic acid or PEG linker (FSC(RGDfE)₃, FSC(succ-RGD)₃, FSC(Mal-RGD)₃). The positron emission tomography/X-ray computed tomography (PET/CT) imaging properties were further compared using [68Ga]FSC(succ-RGD)₃ with the monomeric [68Ga]NODAGA-RGD in a murine tumor model.