A partially purified lipid extracted from Ruditapes philippinarum suppresses cancer cell proliferation

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• 作者：Eun-Kyung Kim ; Yon-Suk Kim ; Jin-Woo Hwang ; Sang-Ho Moon…
• 关键词：Ruditapes philippinarum ; lipid ; apoptosis ; anticancer
• 刊名：Food Science and Biotechnology
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：24
• 期：6
• 页码：2177-2183
• 全文大小：436 KB
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• 作者单位：Eun-Kyung Kim (1)
  Yon-Suk Kim (2)
  Jin-Woo Hwang (2)
  Sang-Ho Moon (1)
  Byong-Tae Jeon (1)
  Pyo-Jam Park (2)
  
  1. Division of Food Bio Science and Korea Nokyong Research Center Konkuk University, Chungju, Chungbuk, 27478, Korea
  2. Department of Biotechnology, Konkuk University, Chungju, Chungbuk, 27478, Korea
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Nutrition
  Food Science
  
• 出版者：The Korean Society of Food Science and Technology in co-publication with Springer
• ISSN：2092-6456

文摘

Anticancer effects of lipids from a clam cultivated in Korea were investigated. Hexane extracts of Ruditapes philippinarum (R. philippinarum) exhibited the highest apoptosis rate of 40.9% at 0.5 mg/mL in PC3 cells. Hexane extracts were further separated and purified using TLC. Final lipid compounds were isolated and identified. Monounsaturated fatty acid and polyunsaturated fatty acid levels were significantly (p<0.05) increased in the purified lipid (19.71 and 34.63%), compared with the crude extract (12.96 and 15.56%). Partially purified lipid compounds exhibited an anticancer effect in several cancer cell lines, resulting in apoptosis rates in breast, lung, and liver cancer cells of 37.36, 17.78, 26.56%, respectively, at 30 μg/mL. This is the first report of an anticancer effect of a lipid extracted from R. philippinarum cultivated in Korea. Keywords Ruditapes philippinarum lipid apoptosis anticancer