Improving the production of acetyl-CoA-derived chemicals in Escherichia coli BL21(DE3) through iclR and arcA deletion

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• 作者：Min Liu ; Yamei Ding ; Hailin Chen ; Zhe Zhao ; Huizhou Liu ; Mo Xian230
• 关键词：Acetyl ; CoA ; Escherichia coli ; iclR ; arcA ; 3 ; hydroxypropionate ; Phloroglucinol
• 刊名：BMC Microbiology
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：17
• 期：1
• 全文大小：946KB
• 刊物主题：Microbiology; Biological Microscopy; Mycology; Parasitology; Virology; Life Sciences, general;
• 出版者：BioMed Central
• ISSN：1471-2180
• 卷排序：17

文摘

BackgroundAcetyl-CoA-derived chemicals are suitable for multiple applications in many industries. The bio-production of these chemicals has become imperative owing to the economic and environmental problems. However, acetate overflow is the major drawback for acetyl-CoA-derived chemicals production. Approaches for overcoming acetate overflow may be beneficial for the production of acetyl-CoA-derived chemicals.