Cytogenetic and oxidative alterations after exposure of cultured human whole blood cells to lithium metaborate dehydrate
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- 作者：Fatih Çağlar Çelikezen ; Başak Toğar ; Fatma Betül Özgeriş…
- 刊名：Cytotechnology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：68
- 期：4
- 页码：821-827
- 全文大小：503 KB
- 刊物类别：Chemistry and Materials Science
- 刊物主题：Chemistry
Biotechnology
Biomedicine
Biochemistry - 出版者：Springer Netherlands
- ISSN：1573-0778
- 卷排序：68
文摘
Boron compounds have an ability of supporting antioxidant properties in human and animal tissues. Lithium metaborate dihydrate (LiBO2·2H2O; LMD) is commonly used in nonlinear optic materials, cellular phones and pagers. But, there are limited data on the genotoxic and antioxidant effects of LMD in cultured human whole blood cells. The aim of this study was to evaluate for the genotoxicity and antioxidant/oxidant activity of LMD on human whole blood lymphocytes (n = 5). LMD was applied at various concentrations (0–1,280 µg/ml) to cultured blood samples. Antioxidant/oxidant activity was evaluated by measuring the total oxidant status (TOS) and total antioxidant capacity levels. Micronuclei and chromosomal aberration tests were used in genotoxicity studies. Our results clearly revealed that all tested concentrations of LMD were found to be non-genotoxic when compared to that of the control group. In addition, LMD exhibited antioxidant activities at low concentrations. In addition the TOS levels were not changed at all concentrations of LMD. Consequently, our results clearly demonstrated that LMD is non-genotoxic and it has an important antioxidant potential in vitro.KeywordsLithium metaborate dihydrateTotal antioxidant capacityTotal oxidant statusMicronucleiChromosomal aberration