HDL-associated ApoM is anti-apoptotic by delivering sphingosine 1-phosphate to S1P1 & S1P3 receptors on vascular endothelium

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• 作者：Mario Ruiz ; Hiromi Okada ; Björn Dahlbäck
• 关键词：ApoM ; Apoptosis ; Endothelial cells ; HDL ; Lipocalins ; Sphingosine 1 ; phospate
• 刊名：Lipids in Health and Disease
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：16
• 期：1
• 全文大小：2377KB
• 刊物主题：Lipidology; Medical Biochemistry; Clinical Nutrition;
• 出版者：BioMed Central
• ISSN：1476-511X
• 卷排序：16

文摘

BackgroundHigh-density Lipoprotein (HDL) attenuates endothelial cell apoptosis induced by different cell-death stimuli such as oxidation or growth factor deprivation. HDL is the main plasma carrier of the bioactive lipid sphingosine 1-phosphate (S1P), which it is a signaling molecule that promotes cell survival in response to several apoptotic stimuli. In HDL, S1P is bound to Apolipoprotein M (ApoM), a Lipocalin that is only present in around 5% of the HDL particles. The goal of this study is to characterize ApoM-bound S1P role in endothelial apoptosis protection and the signaling pathways involved.