Functional effect of Saffron supplementation and risk genotypes in early age-related macular degeneration: a preliminary report
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- 作者：Dario Marangoni (1) (3)
Benedetto Falsini (1)
Marco Piccardi (1)
Lucia Ambrosio (2)
Angelo Maria Minnella (1)
Maria Cristina Savastano (1)
Silvia Bisti (3)
Rita Maccarone (3)
Antonello Fadda (4)
Enrica Mello (5)
Paola Concolino (5)
Ettore Capoluongo (5) - 关键词：Age ; related macular degeneration ; Saffron ; Gene polymorphism ; Electroretinography
- 刊名：Journal of Translational Medicine
- 出版年：2013
- 出版时间：December 2013
- 年：2013
- 卷：11
- 期：1
- 全文大小：404 KB
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Benedetto Falsini (1)
Marco Piccardi (1)
Lucia Ambrosio (2)
Angelo Maria Minnella (1)
Maria Cristina Savastano (1)
Silvia Bisti (3)
Rita Maccarone (3)
Antonello Fadda (4)
Enrica Mello (5)
Paola Concolino (5)
Ettore Capoluongo (5)
1. Dipartimento di Scienze Otorinolaringoiatriche e Oftalmologiche, Universita-Cattolica del Sacro Cuore, Lgo F. Vito 1, 00168, Roma, Italy
3. Dipartimento di Scienze Cliniche ed Applicate Biotecnologiche, DISCAB, Universita-degli Studi dell’Aquila, 67100 L- Aquila, Italy
2. Dipartimento di Scienze Oftalmologiche, Universita-degli Studi di Napoli Federico II, 580131, Napoli, Italy
4. Laboratorio di Ingegneria Biomedica, Istituto Superiore di Sanità, Rome, Italy
5. Istituto di Biochimica Clinica, Universita-Cattolica del Sacro Cuore, Lgo F. Vito 1, 00168, Roma, Italy - ISSN：1479-5876
文摘
Background To determine whether the functional effects of oral supplementation with Saffron, a natural compound that proved to be neuroprotective in early age-related macular degeneration, are influenced by complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2) risk genotypes. Methods Thirty-three early AMD patients, screened for CFH (rs1061170) and ARMS2 (rs10490924) polymorphisms and receiving Saffron oral supplementation (20 mg/day) over an average period of treatment of 11 months (range, 6-2), were longitudinally evaluated by clinical examination and focal electroretinogram (fERG)-derived macular (18°) flicker sensitivity estimate. fERG amplitude and macular sensitivity, the reciprocal value of the estimated fERG amplitude threshold, were the main outcome measures. Results After three months of supplementation, mean fERG amplitude and fERG sensitivity improved significantly when compared to baseline values (p < 0.01). These changes were stable throughout the follow-up period. No significant differences in clinical and fERG improvements were observed across different CFH or ARMS2 genotypes. Conclusions The present results indicate that the functional effect of Saffron supplementation in individual AMD patients is not related to the major risk genotypes of disease.