NGF eye-drops topical administration in patients with retinitis pigmentosa, a pilot study

详细信息    查看全文

• 作者：Benedetto Falsini ; Giancarlo Iarossi…
• 关键词：Retinitis pigmentosa ; Nerve growth factor ; Eye drops ; Photoreceptor ; Focal electroretinogram ; Visual field
• 刊名：Journal of Translational Medicine
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：14
• 期：1
• 全文大小：974 KB
• 参考文献：1.Chang GQ, Hao Y, Wong F. Apoptosis: final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice. Neuron. 1993;11:595–605.CrossRef PubMed
  2.Dryja TP, Li T. Molecular genetics of retinitis pigmentosa. Hum Mol Genet. 1995;4 Spec No:1739–43.PubMed
  3.Punzo C, Xiong W, Cepko CL. Loss of daylight vision in retinal degeneration: are oxidative stress and metabolic dysregulation to blame? J Biol Chem. 2012;287:1642–8.PubMedCentral CrossRef PubMed
  4.Faktorovich EG, Steinberg RH, Yasumura D, Matthes MT, LaVail MM. Photoreceptor degeneration in inherited retinal dystrophy delayed by basic fibroblast growth factor. Nature. 1990;347:83–6.CrossRef PubMed
  5.Hojo M, Abe T, Sugano E, et al. Photoreceptor protection by iris pigment epithelial transplantation transduced with AAV-mediated brain-derived neurotrophic factor gene. Invest Ophthalmol Vis Sci. 2004;45:3721–6.CrossRef PubMed
  6.Kano T, Abe T, Tomita H, et al. Protective effect against ischemia and light damage of iris pigment epithelial cells transfected with the BDNF gene. Invest Ophthalmol Vis Sci. 2002;43:3744–53.PubMed
  7.LaVail MM, Unoki K, Yasumura D, et al. Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light. Proc Natl Acad Sci USA. 1992;89:11249–53.PubMedCentral CrossRef PubMed
  8.LaVail MM, Yasumura D, Matthes MT, et al. Protection of mouse photoreceptors by survival factors in retinal degenerations. Invest Ophthalmol Vis Sci. 1998;39:592–602.PubMed
  9.Lawrence JM, Keegan DJ, Muir EM, et al. Transplantation of Schwann cell line clones secreting GDNF or BDNF into the retinas of dystrophic Royal College of Surgeons rats. Invest Ophthalmol Vis Sci. 2004;45:267–74.CrossRef PubMed
  10.Lambiase A, Aloe L. Nerve growth factor delays retinal degeneration in C3H mice. Graefes Arch Clin Exp Ophthalmol. 1996;234(Suppl 1):S96–100.CrossRef PubMed
  11.Lenzi L, Coassin M, Lambiase A, et al. Effect of exogenous administration of nerve growth factor in the retina of rats with inherited retinitis pigmentosa. Vision Res. 2005;45:1491–500.CrossRef PubMed
  12.Okoye G, Zimmer J, Sung J, et al. Increased expression of brain-derived neurotrophic factor preserves retinal function and slows cell death from rhodopsin mutation or oxidative damage. J Neurosci. 2003;23:4164–72.PubMed
  13.Lambiase A, Tirassa P, Micera A, Aloe L, Bonini S. Pharmacokinetics of conjunctivally applied nerve growth factor in the retina and optic nerve of adult rats. Invest Ophthalmol Vis Sci. 2005;46:3800–6.CrossRef PubMed
  14.Lambiase A, Mantelli F, Sacchetti M, et al. Clinical applications of NGF in ocular diseases. Arch Ital Biol. 2011;149:283–92.PubMed
  15.Chiaretti A, Falsini B, Servidei S, et al. Nerve growth factor eye drop administration improves visual function in a patient with optic glioma. Neurorehabil Neural Repair. 2011;25:386–90.CrossRef PubMed
  16.Falsini B, Chiaretti A, Barone G, et al. Topical nerve growth factor as a visual rescue strategy in pediatric optic gliomas: a pilot study including electrophysiology. Neurorehabil Neural Repair. 2011;25:512–20.CrossRef PubMed
  17.Gargini C, Belfiore MS, Bisti S, et al. The impact of basic fibroblast growth factor on photoreceptor function and morphology. Invest Ophthalmol Vis Sci. 1999;40:2088–99.PubMed
  18.Birch DG, Weleber RG, Duncan JL, Jaffe GJ, Tao W. Ciliary neurotrophic factor retinitis pigmentosa study groups. Randomized trial of ciliary neurotrophic factor delivered by encapsulated cell intraocular implants for retinitis pigmentosa. Am J Ophthalmo. 2013;156(2):283–292.e1.CrossRef
  19.Falsini B, Iarossi G, Fadda A, et al. The fundamental and second harmonic of the photopic flicker electroretinogram: temporal frequency-dependent abnormalities in retinitis pigmentosa. Clin Neurophysiol. 1999;110:1554–62.CrossRef PubMed
  20.Iarossi G, Falsini B, Piccardi M. Regional cone dysfunction in retinitis pigmentosa evaluated by flicker ERGs: relationship with perimetric sensitivity losses. Invest Ophthalmol Vis Sci. 2003;44:866–74.CrossRef PubMed
  21.Eriksdotter Jonhagen M, Nordberg A, Amberla K, et al. Intracerebroventricular infusion of nerve growth factor in three patients with Alzheimer’s disease. Dement Geriatr Cogn Disord. 1998;9:246–57.CrossRef PubMed
  22.Bocchini V, Angeletti PU. The nerve growth factor: purification as a 30,000- molecular-weight protein. Proc Natl Acad Sci USA. 1969;64:787–94.PubMedCentral CrossRef PubMed
  23.Falsini B, Galli-Resta L, Fadda A, et al. Long-term decline of central cone function in retinitis pigmentosa evaluated by focal electroretinogram. Invest Ophthalmol Vis Sci. 2012;53:7701–9.CrossRef PubMed
  24.Bittner AK, Iftikhar MH, Dagnelie G. Test-retest, within-visit variability of Goldmann visual fields in retinitis pigmentosa. Invest Ophthalmol Vis Sci. 2011;52(11):8042–6.PubMedCentral CrossRef PubMed
  25.Lambiase A, Manni L, Rama P, Bonini S. Clinical application of nerve growth factor on human corneal ulcer. Arch Ital Biol. 2003;141:141–8.PubMed
  26.Agarwal N, Agarwal R, Kumar DM, et al. Comparison of expression profile of neurotrophins and their receptors in primary and transformed rat retinal ganglion cells. Mol Vis. 2007;13:1311–8.PubMed
  27.Carmignoto G, Comelli MC, Candeo P, et al. Expression of NGF receptor and NGF receptor mRNA in the developing and adult rat retina. Exp Neurol. 1991;111:302–11.CrossRef PubMed
  28.Garcìa M, Forster V, Hicks D, Vecino E. In vivo expression of neurotrophins and neurotrophin receptors is conserved in adult porcine retina in vitro. Invest Ophthalmol Vis Sci. 2003;44:4532–41.CrossRef PubMed
  29.Nag TC, Wadhwa S. Neurotrophin receptors (Trk A, Trk B, and Trk C) in the developing and adult human retina. Brain Res Dev Brain Res. 1999;117:179–89.CrossRef PubMed
  30.Wahlin KJ, Campochiaro PA, Zack DJ, Adler R. Neurotrophic factors cause activation of intracellular signaling pathways in Muller cells and other cells of the inner retina, but not photoreceptors. Invest Ophthalmol Vis Sci. 2000;4:927–36.
  31.Wahlin KJ, Adler R, Zack DJ, Campochiaro PA. Neurotrophic signaling in normal and degenerating rodent retinas. Exp Eye Res. 2001;73:693–701.CrossRef PubMed
  32.Cachafeiro M, Bemelmans AP, Samardzija M, et al. Hyperactivation of retina by light in mice leads to photoreceptor cell death mediated by VEGF and retinal pigment epithelium permeability. Cell Death Dis. 2013;4:e781.PubMedCentral CrossRef PubMed
  33.Abed E, Corbo G, Falsini B. Neurotrophin family members as neuroprotectans in retinal degenerations. Biodrugs. 2015;29:1–13.CrossRef PubMed
  
• 作者单位：Benedetto Falsini (1)
  Giancarlo Iarossi (2)
  Antonio Chiaretti (3)
  Antonio Ruggiero (3)
  Luigi Manni (4)
  Lucia Galli-Resta (5)
  Giovanni Corbo (1)
  Edoardo Abed (1)
  
  1. Institute of Ophthalmology, Policlinico Gemelli, Catholic University of Sacro Cuore, Lgo F. Vito 1, 00168, Rome, Italy
  2. Ophthalmology Department, Ospedale “Bambin Gesù”, 00165, Rome, Italy
  3. Institute of Pediatrics, Policlinico Gemelli, Catholic University, 00168, Rome, Italy
  4. Translational Pharmacology, CNR, Rome, Italy
  5. Neuroscience Institute, CNR, 56124, Pisa, Italy
  
• 刊物主题：Biomedicine general; Medicine/Public Health, general;
• 出版者：BioMed Central
• ISSN：1479-5876

文摘

Background Preclinical trials have shown beneficial effects of nerve growth factor (NGF) administration on visual function in animal models of retinitis pigmentosa (RP). The aim of this pilot study was to explore the potential efficacy of short term NGF eye drops treatment in patients affected by RP.