文摘
Interferon gamma (IFN-γ) is a potent proinflammatory cytokine which plays a pivotal role in the antiviral, antiproliferative, and antitumor activities. A T-to-A transition at the position +874 of human IFN-γ gene (IFNG) has been reported to influence the secretion of IFN-γ and affect cancer susceptibility. However, results from published studies on the association between IFNG +874 T/A polymorphism and cancer risk are inconclusive or even controversial. In order to derive a more precise estimation of the association, a meta-analysis of 38 eligible studies including 5,630 cases and 6,096 controls was conducted with odds ratio (OR) and its corresponding 95?% confidence interval (95?% CI). Overall, no significant association was detected in allelic model (A allele vs. T allele—OR--.96, 95?% CI, 0.86-.08), homozygote comparison (AA vs. TT—OR--.97, 95?% CI, 0.79-.21), heterozygote comparison (AT vs. TT—OR--.03, 95?% CI, 0.87-.23), dominant model (AA + AT vs. TT—OR--.00, 95?% CI, 0.87-.15), nor recessive model (AA vs. AT + TT—OR--.93, 95?% CI, 0.78-.12). Further subgroup analyses based on ethnicity, cancer types, and Hardy–Weinberg equilibrium status failed to demonstrate any significant relationship except in African population under recessive model (AA vs. AT + TT—OR--.68, 95?% CI, 0.47-.97). In conclusion, the current meta-analysis suggested that IFNG +874 T/A polymorphism may not contribute to cancer susceptibility, and further well-designed studies with large sample size are warranted to validate our conclusion.