The Poitiers School of Mathematical and Theoretical Biology: Besson–Gavaudan–Schützenberger’s Conjectures on Genetic Code and RNA Structures

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• 作者：J. Demongeot ; H. Hazgui
• 关键词：Complex biological networks ; Small RNAs ; Micro ; RNAs ; Circular RNAs ; Dynamic entropy ; Attractor entropy ; Robustness
• 刊名：Acta Biotheoretica
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：64
• 期：4
• 页码：403-426
• 全文大小：
• 刊物类别：Humanities, Social Sciences and Law
• 刊物主题：Philosophy of Biology; Evolutionary Biology;
• 出版者：Springer Netherlands
• ISSN：1572-8358
• 卷排序：64

文摘

The French school of theoretical biology has been mainly initiated in Poitiers during the sixties by scientists like J. Besson, G. Bouligand, P. Gavaudan, M. P. Schützenberger and R. Thom, launching many new research domains on the fractal dimension, the combinatorial properties of the genetic code and related amino-acids as well as on the genetic regulation of the biological processes. Presently, the biological science knows that RNA molecules are often involved in the regulation of complex genetic networks as effectors, e.g., activators (small RNAs as transcription factors), inhibitors (micro-RNAs) or hybrids (circular RNAs). Examples of such networks will be given showing that (1) there exist RNA “relics” that have played an important role during evolution and have survived in many genomes, whose probability distribution of their sub-sequences is quantified by the Shannon entropy, and (2) the robustness of the dynamics of the networks they regulate can be characterized by the Kolmogorov–Sinaï dynamic entropy and attractor entropy.