The Influence of Nitrogen Dioxide on Arrhythmias in Spain and Its Relationship with Atmospheric Circulation

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• 作者：Ana Santurtún ; Arturo Sanchez-Lorenzo ; Alejandro Villar…
• 关键词：Arrhythmia ; Air pollution ; Nitrogen dioxide ; Atmospheric circulation ; Spain
• 刊名：Cardiovascular Toxicology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：17
• 期：1
• 页码：88-96
• 全文大小：
• 刊物主题：Pharmacology/Toxicology; Cardiology;
• 出版者：Springer US
• ISSN：1559-0259
• 卷排序：17

文摘

Epidemiological studies suggest that increased ambient NO₂ concentrations are associated with cardiovascular disease. However, none of them have examined the association between ambient air pollution and cardiac arrhythmias in the general population in Spain. This paper assesses the short-term association between the aforementioned air pollutant and hospital admissions for arrhythmia in nine different regions of Spain during a 6-year period (2005–2010), and the possible season-specific effects of the compound on this pathology, by performing a time-series analysis based on Poisson regression models. The results show statistically significant positive relationship increases between arrhythmia admissions and increments in NO₂ concentration during the whole year, most notably in wintertime. Moreover, while trying to establish a threshold for NO₂ concentration above which the incidence of arrhythmia episodes increases significantly, this study reveals that hospital admissions increased linearly in response to an increase in as we move to higher NO₂ concentration levels. Finally, an analysis of NO₂ concentrations and their relationship with atmospheric circulation is performed, showing higher values of NO₂ under anticyclonic conditions during winter that could be used for implementing pollution level alert protocols depending on forecast circulation patterns.