ATP-binding cassette transporter A1 gene polymorphisms and serum lipid levels in young Greek nurses
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- 作者：Vana Kolovou (1)
Genovefa Kolovou (2)
Apostolia Marvaki (1)
Agathi Karakosta (3)
Georgios Vasilopoulos (4)
Antonia Kalogiani (4)
Dimitrios Degiannis (1)
Christina Marvaki (4)
Constantinos A Demopoulos (5) - 刊名：Lipids in Health and Disease
- 出版年：2011
- 出版时间：December 2011
- 年：2011
- 卷：10
- 期：1
- 全文大小：528KB
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Genovefa Kolovou (2)
Apostolia Marvaki (1)
Agathi Karakosta (3)
Georgios Vasilopoulos (4)
Antonia Kalogiani (4)
Dimitrios Degiannis (1)
Christina Marvaki (4)
Constantinos A Demopoulos (5)
1. Molecular Immunology Laboratory, Onassis Cardiac Surgery Center Athens, Athens, Greece
2. 1st Cardiology Department, Onassis Cardiac Surgery Center Athens, Athens, Greece
3. Thriassio General Hospital, Magoula, Attica, Greece
4. Department of Nursing, A鈥?Technological Educational Institute of Athens, Athens, Greece
5. Department of Chemistry, National and Kapodistrian University of Athens, Athens, Greece
文摘
Objective The ATP-binding cassette transporter A1 (ABCA1) is essential protein involved in lipid metabolism. The present study was undertaken to detect the possible association of polymorphisms in the ABCA1 gene [rs2230806 (R219K) and rs2230808 (R1587K)] and lipid profile in Greek young nurses. Methods The study population consisted of 308 unrelated nurses who were genotyped and the ABCA1 polymorphisms were detected. Additionally, lipid profile [total cholesterol (TC), triglycerides (TGs), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and apolipoprotein (apo) A] was evaluated. Results There was no difference in the genotypic and allelic frequencies of the R219K polymorphism according to lipid profile. The R1587K genotypes differed significantly according to TC, LDL-C and TGs concentration (p = 0.023, p = 0.014 and p = 0.047, respectively). Particularly, significant difference in TC, LDL-C and TGs concentration was detected between RK and RR genotypes (p = 0.006, p = 0.004, p = 0.014, respectively). Women with RK genotype compared to RR genotype had higher concentration of TGs (134.25 mg/dl vs 108.89 mg/dl, p = 0.014, respectively), total cholesterol (207.41 mg/dl vs 187.69 mg/dl, p = 0.006, respectively), and LDL-C (110.6 mg/dl vs 96.9 mg/dl, p = 0.004, respectively). Conclusions These findings suggest that the R1587K polymorphism of ABCA1 gene was associated with lipid profile of Greek nurses. Women with RK genotype had higher TGs, total and LDL-C concentration compared to RR genotype. These observations may be significant in assessing the risk of CAD since a 1% change in LDL-C is associated with a 1% change of cardiovascular events. Also, TGs concentration were documented to play a significant role in women. However, this needs to be confirmed by larger studies.