Genetic variation underlying renal uric acid excretion in Hispanic children: the Viva La Familia Study

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• 作者：Geetha Chittoor ; Karin Haack ; Nitesh R. Mehta ; Sandra Laston…
• 关键词：Uric acid clearance ; Genetic variation ; Fractional excretion of uric acid ; Hispanic children
• 刊名：BMC Medical Genetics
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：18
• 期：1
• 全文大小：925KB
• 刊物主题：Human Genetics; Cytogenetics; Gene Function;
• 出版者：BioMed Central
• ISSN：1471-2350
• 卷排序：18

文摘

BackgroundReduced renal excretion of uric acid plays a significant role in the development of hyperuricemia and gout in adults. Hyperuricemia has been associated with chronic kidney disease and cardiovascular disease in children and adults. There are limited genome-wide association studies associating genetic polymorphisms with renal urate excretion measures. Therefore, we investigated the genetic factors that influence the excretion of uric acid and related indices in 768 Hispanic children of the Viva La Familia Study.