Dependence of the quality of SALDI TOF MS analysis on the TiO2 nanocrystals' size and shape

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• 作者：Iva Popović ; Dubravka Milovanović ; Jadranka Miletić…
• 关键词：SALDI TOF MS ; TiO2 nanocrystals ; Homogeneity
• 刊名：Optical and Quantum Electronics
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：48
• 期：2
• 全文大小：457 KB
• 参考文献：Arakawa, R., Kawasaki, H.: Functionalized nanoparticles and nanostructured surfaces for surface-assisted laser desorption/ionization mass spectrometry. Anal. Sci. Int. J. Japan Soc. Anal. Chem. 26, 1229–1240 (2010)CrossRef
  Kasuga, T., Hiramatsu, M., Hoson, A., Sekino, T., Niihara, K.: Titania nanotubes prepared by chemical processing. Adv. Mater. 11, 1307–1311 (1999)CrossRef
  Linsebigler, A.L., Lu, G., Yates, J.T.: Photocatalysis on TiO2 surfaces: principles, mechanisms, and selected results. Chem. Rev. 95, 735–758 (1995)CrossRef
  Rajh, T., Tiede, D.M., Thurnauer, M.C.: Surface modification of TiO2 nanoparticles with bidentate ligands studied by EPR spectroscopy. J. Non. Cryst. Solids. 205–207, 815–820 (1996)CrossRef
  Silina, Y.E., Volmer, D.A.: Nanostructured solid substrates for efficient laser desorption/ionization mass spectrometry (LDI-MS) of low molecular weight compounds. Analyst. 138, 7053–7065 (2013)CrossRef ADS
  Stolee, J.A., Walker, B.N., Zorba, V., Russo, R.E., Vertes, A.: Laser–nanostructure interactions for ion production. Phys. Chem. Chem. Phys. 14, 8453–8471 (2012)CrossRef
  Thompson, R.C.: Oxidation of peroxotitanium(IV) by chlorine and cerium(IV) in acidic perchlorate solution. Inorg. Chem. 23, 1794–1798 (1984)CrossRef
  Watanabe, T., Okumura, K., Kawasaki, H., Arakawa, R.: Effect of urea surface modification and photocatalytic cleaning on surface-assisted laser desorption ionization mass spectrometry with amorphous TiO2 nanoparticles. J. Mass Spectrom. 44, 1443–1451 (2009)CrossRef
  
• 作者单位：Iva Popović (1)
  Dubravka Milovanović (1)
  Jadranka Miletić (1)
  Maja Nešić (1)
  Mila Vranješ (1)
  Zoran Šaponjić (1)
  Marijana Petković (1)
  
  1. Institute of Nuclear Sciences “Vinča”, University of Belgrade, Mike Petrovića Alasa 12-14, Belgrade, Serbia
  
• 刊物主题：Optics, Optoelectronics, Plasmonics and Optical Devices; Electrical Engineering; Characterization and Evaluation of Materials; Computer Communication Networks;
• 出版者：Springer US
• ISSN：1572-817X

文摘

Titanium dioxide is widely used substrate for laser desorption and ionization [(SA)LDI] mass spectrometry. As the semiconductor with high UV absorbance and rapid energy transfer to analytes, TiO₂ provides soft and efficient desorption/ionization of analytes with relatively low degrees of fragmentation in the gas phase. TiO₂ nanocrystals are convenient for small molecules (molecular mass <1000 Da) analysis due to low number of background signals. Desorption/ionization processes on TiO₂ nanocrystals are related to the physical properties of the substrate, such as the ability to absorb and dissipate energy from the irradiating laser light source. In addition, size and shape of nanocrystals also affect these abilities. The aim of this study is to investigate the influence of shape and size dependant TiO₂ nanocrystals/UV laser interaction on the quality of the mass spectra, detectability of analyzed molecules, intensities of the signals and homogeneity of co-crystals onto the MALDI plate, of carbohydrates. It is shown that the size and shape of nanocrystals influenced the way of packing carbohydrates onto plate, and thus affects homogeneity and reproducibility of mass spectrometry analysis.