Protein tyrosine phosphatase PTP-RR regulates corticosteroid sensitivity
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- 作者：Yoshiki Kobayashi ; Kazuhiro Ito ; Akira Kanda ; Koich Tomoda…
- 关键词：Corticosteroid insensitivity ; Glucocorticoid receptor ; PP2A ; PTP ; RR ; Severe asthma
- 刊名：Respiratory Research
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：17
- 期：1
- 全文大小：1,621 KB
- 刊物主题：Pneumology/Respiratory System;
- 出版者：BioMed Central
- ISSN：1465-9921
文摘
Background We have recently reported that protein phosphate 2A (PP2A) inactivation resulted in increased phosphorylation of the mitogen-activated protein kinase (MAPK) c-Jun N-terminal kinase 1 (JNK1) and glucocorticoid receptors (GR) at Ser226, thereby reducing GR nuclear translocation and causing corticosteroid insensitivity in severe asthmatics. Protein tyrosine phosphatases (PTPs) are also known to be critically involved in the regulation of MAPKs, such as JNK and therefore potentially associated with GR function. The aim of study was to elucidate the involvement of MAPK-PTPs (PTP-RR, PTP-N5 and PTP-N7), which can dephosphorylate MAPKs, in the regulation of corticosteroid sensitivity.