Development and Characterization of Sorbitan Monostearate and Sesame Oil-Based Organogels for Topical Delivery of Antimicrobials
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- 作者：Vinay K. Singh ; Krishna Pramanik ; Sirsendu S. Ray ; Kunal Pal
- 关键词：organogel ; phase contrast microscopy ; sesame oil ; sorbitan monostearate
- 刊名：AAPS PharmSciTech
- 出版年：2015
- 出版时间：April 2015
- 年：2015
- 卷：16
- 期：2
- 页码：293-305
- 全文大小：3,803 KB
- 参考文献：1. Pal, A, Dey, J (2011) Water-induced physical gelation of organic solvents by N-(n-alkylcarbamoyl)-l-alanine amphiphiles. Langmuir 27: pp. 3401-8 CrossRef
2. Landry, CJT, Coltrain, BK, Brady, BK (1992) In situ polymerization of tetraethoxysilane in poly (methyl methacrylate): morphology and dynamic mechanical properties. Polymer 33: pp. 1486-95 CrossRef
3. Placin, F, Colomès, M, Desvergne, JP (1997) A new example of small molecular non-hydrogen bonding gelators for organic solvents. Tetrahedron Lett 38: pp. 2665-8 CrossRef
4. George M, Weiss RG. Low molecular-mass organic gelators. Mol Gels. 2006:449-51.
5. Hughes, NE, Marangoni, AG, Wright, AJ, Rogers, MA, Rush, JWE (2009) Potential food applications of edible oil organogels. Trends Food Sci Technol 20: pp. 470-80 CrossRef
6. Stanos, SP (2007) Topical agents for the management of musculoskeletal pain. J Pain Symptom Manag 33: pp. 342-55 CrossRef
7. Patil VV. Span-60 based organogels as probable matrices for transdermal/topical delivery systems 2011.
8. Murdan, S, Gregoriadis, G, Florence, AT (1999) Novel sorbitan monostearate organogels. J Pharm Sci 88: pp. 608-14 CrossRef
9. Daniel, J, Rajasekharan, R (2003) Organogelation of plant oils and hydrocarbons by long-chain saturated FA, fatty alcohols, wax esters, and dicarboxylic acids. J Am Oil Chem Soc 80: pp. 417-21 CrossRef
10. Toro-Vazquez, J, Morales-Rueda, J, Dibildox-Alvarado, E, Charo-Alonso, M, Alonzo-Macias, M, Gonzalez-Chavez, M (2007) Thermal and textural properties of organogels developed by candelilla wax in safflower oil. J Am Oil Chem Soc 84: pp. 989-1000 CrossRef
11. Bhattacharya, C, Kumar, N, Sagiri, SS, Pal, K, Ray, SS (2012) Development of span 80–tween 80 based fluid-filled organogels as a matrix for drug delivery. J Pharm bioallied Sci 4: pp. 155 CrossRef
12. Wright, AJ, Marangoni, AG, Garti, N (2011) Vegetable oil-based ricinelaidic acid organogels—phase behavior, microstructure and rheology. Edible oleogels: structure and health implications. AOCS Press, Urbana, pp. 81-99
13. Shah, DK, Sagiri, SS, Behera, B, Pal, K, Pramanik, K (2013) Development of olive oil based organogels using sorbitan monopalmitate and sorbitan monostearate: a comparative study. J Appl Polym Sci 129: pp. 793-805 CrossRef
14. Peyronel, F, Marangoni, AG (2014) In search of confectionary fat blends stable to heat: hydrogenated palm kernel oil stearin with sorbitan monostearate. Food Res Int 55: pp. 93-102 CrossRef
15. Bedigian, D, Seigler, DS, Harlan, JR (1985) Sesamin, sesamolin and the origin of sesame. Biochem Syst Ecol 13: pp. 133-9 CrossRef
16. Wei, W, Qi, X, Wang, L, Zhang, Y, Hua, W, Li, D (2011) Characterization of the sesame (Sesamum indicum L.) global transcriptome using Illumina paired-end sequencing and development of EST-SSR markers. BMC Genomics 12: pp. 451 CrossRef
17. Periasamy, S, Chien, S-P, Chang, P-C, Hsu, D-Z, Liu, M-Y (2014) Sesame oil mitigates nutritional steatohepatitis via attenuation of oxidative stress and inflammation: a tale of two-hit hypothesis. J Nutr Biochem 25: pp. 232-40 CrossRef
18. Suja, K, Jayalekshmy, A, Arumughan, C (2005) Antioxidant activity of sesame cake extract. Food Chem 91: pp. 213-9- 刊物主题：Pharmacology/Toxicology; Biotechnology; Biochemistry, general; Pharmacy;
- 出版者：Springer US
- ISSN：1530-9932
文摘
The current study explains the development of sorbitan monostearate and sesame oil-based organogels for topical drug delivery. The organogels were prepared by dissolving sorbitan monostearate in sesame oil (70°C). Metronidazole was used as a model antimicrobial. The formulations were characterized using phase contrast microscopy, infrared spectroscopy, viscosity, mechanical test, and differential scanning calorimetry. Phase contrast microscopy showed the presence of needle-shaped crystals in the organogel matrix. The length of the crystals increased with the increase in the sorbitan monostearate concentration. XRD studies confirmed the amorphous nature of the organogels. Viscosity study demonstrated shear thinning behavior of the organogels. The viscosity and the mechanical properties of the organogels increased linearly with the increase in the sorbitan monostearate concentration. Stress relaxation study confirmed the viscoelastic nature of the organogels. The organogels were biocompatible. Metronidazole-loaded organogels were examined for their controlled release applications. The release of the drug followed zero-order release kinetics. The drug-loaded organogels showed almost similar antimicrobial activity against Escherichia coli when compared to the commercially available Metrogyl? gel. In gist, it can be proposed that the developed organogels had sufficient properties to be used for controlled delivery of drugs.