Behavioral and Molecular Genetics of Reading-Related AM and FM Detection Thresholds
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- 作者：Matthew Bruni ; Judy F. Flax ; Steven Buyske ; Amber D. Shindhelm…
- 关键词：Dynamic auditory sensitivity ; AM processing ; FM processing ; Heritability ; Language ; Reading
- 刊名：Behavior Genetics
- 出版年：2017
- 出版时间：March 2017
- 年：2017
- 卷：47
- 期：2
- 页码：193-201
- 全文大小：
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Clinical Psychology; Health Psychology; Public Health;
- 出版者：Springer US
- ISSN：1573-3297
- 卷排序：47
文摘
Auditory detection thresholds for certain frequencies of both amplitude modulated (AM) and frequency modulated (FM) dynamic auditory stimuli are associated with reading in typically developing and dyslexic readers. We present the first behavioral and molecular genetic characterization of these two auditory traits. Two extant extended family datasets were given reading tasks and psychoacoustic tasks to determine FM 2 Hz and AM 20 Hz sensitivity thresholds. Univariate heritabilities were significant for both AM (h2 = 0.20) and FM (h2 = 0.29). Bayesian posterior probability of linkage (PPL) analysis found loci for AM (12q, PPL = 81 %) and FM (10p, PPL = 32 %; 20q, PPL = 65 %). Bivariate heritability analyses revealed that FM is genetically correlated with reading, while AM was not. Bivariate PPL analysis indicates that FM loci (10p, 20q) are not also associated with reading.