Changes in stress-stimulated allopregnanolone levels induced by neonatal estradiol treatment are associated with enhanced dopamine release in adult female rats: reversal by progesterone administration
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- 作者：Patrizia Porcu ; Valeria Lallai ; Andrea Locci ; Sandro Catzeddu…
- 关键词：Neonatal estradiol ; Stress ; Allopregnanolone ; Dopamine ; Corticosterone ; Female rat
- 刊名：Psychopharmacology
- 出版年：2017
- 出版时间：March 2017
- 年：2017
- 卷：234
- 期：5
- 页码：749-760
- 全文大小：
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Neurosciences; Pharmacology/Toxicology; Psychiatry;
- 出版者：Springer Berlin Heidelberg
- ISSN：1432-2072
- 卷排序：234
文摘
BackgroundAllopregnanolone plays a role in the stress response and homeostasis. Alterations in the estrogen milieu during the perinatal period influence brain development in a manner that persists into adulthood. Accordingly, we showed that a single administration of estradiol benzoate (EB) on the day of birth decreases brain allopregnanolone concentrations in adult female rats.