C₆₀ Fullerene as Promising Therapeutic Agent for the Prevention and Correction of Skeletal Muscle Functioning at Ischemic Injury

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• 作者：D. M. Nozdrenko ; D. O. Zavodovskyi ; T. Yu. Matvienko…
• 关键词：C60 fullerene ; Skeletal muscle ; Ischemia ; Muscle contraction dynamics ; Biochemical analysis
• 刊名：Nanoscale Research Letters
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：12
• 期：1
• 全文大小：1152KB
• 刊物主题：Nanotechnology; Nanotechnology and Microengineering; Nanoscale Science and Technology; Nanochemistry; Molecular Medicine;
• 出版者：Springer US
• ISSN：1556-276X
• 卷排序：12

文摘

The therapeutic effect of pristine C₆₀ fullerene aqueous colloid solution (C₆₀FAS) on the functioning of the rat soleus muscle at ischemic injury depending on the time of the general pathogenesis of muscular system and method of administration C₆₀FAS in vivo was investigated. It was found that intravenous administration of C₆₀FAS is the optimal for correction of speed macroparameters of contraction for ischemic muscle damage. At the same time, intramuscular administration of C₆₀FAS shows pronounced protective effect in movements associated with the generation of maximum force responses or prolonged contractions, which increase the muscle fatigue level. Analysis of content concentration of creatine phosphokinase and lactate dehydrogenase enzymes in the blood of experimental animals indicates directly that C₆₀FAS may be a promising therapeutic agent for the prevention and correction of ischemic-damaged skeletal muscle function.