EVERREST prospective study: a 6-year prospective study to define the clinical and biological characteristics of pregnancies affected by severe early onset fetal growth restriction
详细信息 查看全文
- 作者：Rebecca Spencer ; Gareth Ambler ; Jana Brodszki ; Anke Diemert…
- 关键词：Fetal growth restriction ; Prospective cohort ; Ultrasound biometry ; Doppler ultrasound ; Angiogenic ; Prediction ; Outcome ; Uteroplacental ; Placental insufficiency
- 刊名：BMC Pregnancy and Childbirth
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：17
- 期：1
- 全文大小：704KB
- 刊物主题：Reproductive Medicine; Maternal and Child Health; Gynecology;
- 出版者：BioMed Central
- ISSN：1471-2393
- 卷排序：17
文摘
BackgroundFetal growth restriction (FGR) is a serious obstetric condition for which there is currently no treatment. The EVERREST Prospective Study has been designed to characterise the natural history of pregnancies affected by severe early onset FGR and establish a well phenotyped bio-bank. The findings will provide up-to-date information for clinicians and patients and inform the design and conduct of the EVERREST Clinical Trial: a phase I/IIa trial to assess the safety and efficacy of maternal vascular endothelial growth factor (VEGF) gene therapy in severe early onset FGR. Data and samples from the EVERREST Prospective Study will be used to identify ultrasound and/or biochemical markers of prognosis in pregnancies with an estimated fetal weight (EFW) <3rd centile between 20+0 and 26+6 weeks of gestation.