A fission yeast cell-based system for multidrug resistant HIV-1 proteases

详细信息    查看全文

• 作者：Zsigmond Benko ; Dong Liang ; Ge Li ; Robert T. Elder ; Anindya Sarkar…
• 关键词：HIV ; 1 ; Multidrug resistant proteases ; Fission yeast ; Proteolytic cleavage ; Cell proliferation ; Oxidative stress ; Mitochondria ; Cell death ; Protease inhibitors
• 刊名：Cell & Bioscience
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：7
• 期：1
• 全文大小：3758KB
• 刊物主题：Cell Biology; Microbiology; Stem Cells; Neurobiology; Proteomics;
• 出版者：BioMed Central
• ISSN：2045-3701
• 卷排序：7

文摘

BackgroundHIV-1 protease (PR) is an essential enzyme for viral production. Thus, PR inhibitors (PIs) are the most effective class of anti-HIV drugs. However, the main challenge to the successful use of PI drugs in patient treatment is the emergence of multidrug resistant PRs (_mdrPRs). This study aimed to develop a fission yeast cell-based system for rapid testing of new PIs that combat _mdrPRs.