A novel RING finger in the C-terminal domain of the coatomer protein α-COP

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• 作者：Gurmeet Kaur ; Srikrishna Subramanian
• 关键词：Cellular transport ; Coat protein ; Coated vesicles ; Tethering complex ; Zinc finger
• 刊名：Biology Direct
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：10
• 期：1
• 全文大小：1,922 KB
• 刊物主题：Life Sciences, general;
• 出版者：BioMed Central
• ISSN：1745-6150

文摘

The C-terminal domain of α-COP, an essential subunit of the COPI coatomer complex, is composed of an all α-helical region and a small β-sheet domain. We show that this β-sheet domain is a Really Interesting New Gene (RING)-like treble clef zinc finger. The zinc-binding residues are substituted by other aminoacids in many homologs including the structurally-characterized proteins from Saccharomyces cerevisiae and Bos taurus. This RING-like domain is possibly related to those of other vesicle membrane-associated complexes, such as CORVET, HOPS and SEA, and likely mediates interactions with Dsl1p and assist in coat oligomerization.