Inhibition of dynamin-related protein 1 protects against myocardial ischemia–reperfusion injury in diabetic mice

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• 作者：Mingge Ding ; Qianqian Dong ; Zhenghua Liu ; Zheng Liu…
• 关键词：Drp1 ; Mitochondrial fission ; Diabetes ; Ischemia–reperfusion
• 刊名：Cardiovascular Diabetology
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：16
• 期：1
• 全文大小：2410KB
• 刊物主题：Diabetes; Angiology; Cardiology;
• 出版者：BioMed Central
• ISSN：1475-2840
• 卷排序：16

文摘

BackgroundMany cardioprotective pharmacological agents failed to exert their protective effects in diabetic hearts subjected to myocardial ischemia/reperfusion (MI/R). Identify the molecular basis linking diabetes with MI/R injury is scientifically important and may provide effective therapeutic approaches. Dynamin-related protein 1 (Drp1)-mediated mitochondrial fission plays an important role in MI/R injury under non-diabetic conditions. Importantly, recent studies indicated that Drp1-mediated mitochondrial fission is enhanced in the myocardium of diabetic mice. The above evidences suggested that Drp1 may be one critical molecule linking diabetes with MI/R injury. We hypothesized that inhibition of Drp1 may be effective to reduce MI/R injury in diabetic hearts.