Regulation of SCN3B/scn3b by Interleukin 2 (IL-2): IL-2 modulates SCN3B/scn3b transcript expression and increases sodium current in myocardial cells

详细信息    查看全文

• 作者：Yuanyuan Zhao ; Qiaobing Sun ; Zhipeng Zeng ; Qianqian Li…
• 关键词：Interleukin ; 2 ; SCN3B ; Sodium current density ; p53
• 刊名：BMC Cardiovascular Disorders
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：16
• 期：1
• 全文大小：1,038 KB
• 参考文献：1.Gungor B, Ekmekci A, Arman A, Ozcan KS, Ucer E, Alper AT, et al. Assessment of Interleukin‐1 Gene Cluster Polymorphisms in Lone Atrial Fibrillation: New Insight into the Role of Inflammation in Atrial Fibrillation. Pacing Clin Electrophysiol. 2013;36:1220–7.PubMed
  2.Guo Y, Lip GY, Apostolakis S. Inflammation in atrial fibrillation. J Am Coll Cardiol. 2012;60:2263–70.PubMed CrossRef
  3.Ishii Y, Schuessler RB, Gaynor SL, Yamada K, Fu AS, Boineau JP, et al. Inflammation of atrium after cardiac surgery is associated with inhomogeneity of atrial conduction and atrial fibrillation. Circulation. 2005;111:2881–8.PubMed CrossRef
  4.Friedrichs K, Klinke A, Baldus S. Inflammatory pathways underlying atrial fibrillation. Trends Mol Med. 2011;17:556–63.PubMed CrossRef
  5.Guglin M, Aljayeh M, Saiyad S, Ali R, Curtis AB. Introducing a new entity: chemotherapy-induced arrhythmia. Europace. 2009;11:1579–86.PubMed CrossRef
  6.Rizos I, Tsiodras S, Rigopoulos AG, Dragomanovits S, Kalogeropoulos AS, Papathanasiou S, et al. Interleukin-2 serum levels variations in recent onset atrial fibrillation are related with cardioversion outcome. Cytokine. 2007;40:157–64.PubMed CrossRef
  7.Hak L, Mysliwska J, Wieckiewicz J, Szyndler K, Siebert J, Rogowski J. Interleukin-2 as a predictor of early postoperative atrial fibrillation after cardiopulmonary bypass graft (CABG). J Interferon Cytokine Res. 2009;29:327–32.PubMed CrossRef
  8.Olesen MS, Andreasen L, Jabbari J, Refsgaard L, Haunso S, Olesen SP, et al. Very early-onset lone atrial fibrillation patients have a high prevalence of rare variants in genes previously associated with atrial fibrillation. Heart Rhythm. 2014;11:246–51.PubMed CrossRef
  9.Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative CT method. Nat Protoc. 2008;3:1101–8.PubMed CrossRef
  10.Hakim P, Brice N, Thresher R, Lawrence J, Zhang Y, Jackson AP, et al. Scn3b knockout mice exhibit abnormal sino-atrial and cardiac conduction properties. Acta Physiol (Oxf). 2010;198:47–59.CrossRef
  11.Wu L, Yong SL, Fan C, Ni Y, Yoo S, Zhang T, et al. Identification of a new co-factor, MOG1, required for the full function of cardiac sodium channel Nav 1.5. J Biol Chem. 2008;283:6968–78.PubMed CrossRef
  12.Zeng Z, Zhou J, Hou Y, Liang X, Zhang Z, Xu X, et al. Electrophysiological characteristics of a SCN5A voltage sensors mutation R1629Q associated with Brugada syndrome. PLoS One. 2013;8:e78382.PubMed PubMedCentral CrossRef
  13.Watanabe M, Moon KD, Vacchio MS, Hathcock KS, Hodes RJ. Downmodulation of tumor suppressor p53 by T cell receptor signaling is critical for antigen-specific CD4(+) T cell responses. Immunity. 2014;40:681–91.PubMed PubMedCentral CrossRef
  14.Adachi K, Toyota M, Sasaki Y, Yamashita T, Ishida S, Ohe-Toyota M, et al. Identification of SCN3B as a novel p53-inducible proapoptotic gene. Oncogene. 2004;23:7791–8.PubMed CrossRef
  15.Maier SK, Westenbroek RE, McCormick KA, Curtis R, Scheuer T, Catterall WA. Distinct subcellular localization of different sodium channel α and β subunits in single ventricular myocytes from mouse heart. Circulation. 2004;109:1421–7.PubMed CrossRef
  16.Cao CM, Xia Q, Bruce IC, Zhang X, Fu C, Chen JZ. Interleukin-2 increases activity of sarcoplasmic reticulum Ca2 + −ATPase, but decreases its sensitivity to calcium in rat cardiomyocytes. J Pharmacol Exp Ther. 2003;306:572–80.PubMed CrossRef
  17.Hu D, Barajas-Martinez H, Burashnikov E, Springer M, Wu Y, Varro A, et al. A mutation in the beta 3 subunit of the cardiac sodium channel associated with Brugada ECG phenotype. Circ Cardiovasc Genet. 2009;2:270–8.PubMed PubMedCentral CrossRef
  18.Valdivia CR, Medeiros-Domingo A, Ye B, Shen WK, Algiers TJ, Ackerman MJ, et al. Loss-of-function mutation of the SCN3B-encoded sodium channel {beta}3 subunit associated with a case of idiopathic ventricular fibrillation. Cardiovasc Res. 2010;86:392–400.PubMed PubMedCentral CrossRef
  19.Wang P, Yang Q, Wu X, Yang Y, Shi L, Wang C, et al. Functional dominant-negative mutation of sodium channel subunit gene SCN3B associated with atrial fibrillation in a Chinese GeneID population. Biochem Biophys Res Commun. 2010;398:98–104.PubMed PubMedCentral CrossRef
  20.Olesen MS, Jespersen T, Nielsen JB, Liang B, Moller DV, Hedley P, et al. Mutations in sodium channel beta-subunit SCN3B are associated with early-onset lone atrial fibrillation. Cardiovasc Res. 2011;89:786–93.PubMed CrossRef
  21.Hakim P, Brice N, Thresher R, Lawrence J, Zhang Y, Jackson A, et al. Scn3b knockout mice exhibit abnormal sino‐atrial and cardiac conduction properties. Acta Physiol. 2010;198:47–59.CrossRef
  22.Ishikawa T, Takahashi N, Ohno S, Sakurada H, Nakamura K, On YK, et al. Novel SCN3B mutation associated with Brugada syndrome affects intracellular trafficking and function of Nav1.5. Circ J. 2013;77:959–67.PubMed CrossRef
  
• 作者单位：Yuanyuan Zhao (1)
  Qiaobing Sun (2)
  Zhipeng Zeng (3)
  Qianqian Li (1)
  Shiyuan Zhou (4)
  Mengchen Zhou (1)
  Yumei Xue (5)
  Xiang Cheng (3)
  Yunlong Xia (2)
  Qing Wang (1)
  Xin Tu (1)
  
  1. Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Cardio-X Institute, Huazhong University of Science and Technology, Wuhan, 430074, China
  2. First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China
  3. The Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, 430074, China
  4. Henan Research Institute of Population and Family Planning, National Health and Family Planning Commission Key Laboratory of Birth Defects Prevention, Zhengzhou, 450002, China
  5. Department of Cardiology, Guangdong General Hospital, Guangdong, 510030, China
  
• 刊物主题：Cardiology; Cardiac Surgery; Angiology; Blood Transfusion Medicine; Internal Medicine;
• 出版者：BioMed Central
• ISSN：1471-2261

文摘

Background In the initiation and maintenance of arrhythmia, inflammatory processes play an important role. IL-2 is a pro-inflammatory factor which is associated with the morbidity of arrhythmias, however, how IL-2 affects the cardiac electrophysiology is still unknown.