Antihyperglycemic and antioxidant activities of total alkaloids from Catharanthus roseus in streptozotocin-induced diabetic rats

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• 作者：Lin Zhang ; Gang Wei ; Yang Liu ; Yuangang Zu ; Qinghui Gai…
• 关键词：Antihyperglycemic activity ; Antioxidant activity ; Catharanthus roseus ; Streptozotocin ; induced diabetic rats ; Total alkaloids
• 刊名：Journal of Forestry Research
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：27
• 期：1
• 页码：167-174
• 全文大小：528 KB
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• 作者单位：Lin Zhang (1)
  Gang Wei (1)
  Yang Liu (1)
  Yuangang Zu (1)
  Qinghui Gai (1)
  Lei Yang (1)
  
  1. Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin, 150040, People’s Republic of China
  
• 刊物主题：Forestry;
• 出版者：Springer Berlin Heidelberg
• ISSN：1993-0607

文摘

We evaluated the hypoglycemic and antioxidant effects of the total alkaloids of leaves and twigs of Catharanthus roseus Linn. (CTA) in streptozotocin (STZ)-induced diabetic rats. The hypoglycemic effect was measured by blood glucose and plasma insulin level. Oxidative stress was measured in heart, liver and kidney by levels of antioxidant markers, free radical scavengers and lipid peroxides i.e. superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and thiobarbituric acid reactive substances (TBARS). Biochemical parameters, i.e. aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphate (ALP) were observed in diabetic control and treated rats. Oral administration of CTA for 30 days was followed by a significant (P < 0.05) decrease in fasting blood glucose and increase in insulin level as compared with untreated diabetic rats. Also it significantly (P < 0.05) reduced ALT, AST and ALP. The treatment also resulted in significant (P < 0.05) reductions in GSH, SOD, CAT, and decrease in TBARS in the heart, liver and kidney of diabetic rats. The results suggest that CTA can effectively normalize the impaired antioxidant status in STZ-induced diabetes in a dose-dependent manner. CTA exerted rapid protective effects against lipid peroxidation by scavenging of free radicals and reducing the risk of diabetic complications.