Targeted p53 activation by saRNA suppresses human bladder cancer cells growth and metastasis
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- 作者：Chenghe Wang ; Qiangqiang Ge ; Qingsong Zhang…
- 关键词：RNA activation ; saRNA ; Bladder cancer ; Proliferation ; Metastasis
- 刊名：Journal of Experimental & Clinical Cancer Research
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：35
- 期：1
- 全文大小：3,791 KB
- 刊物主题：Oncology; Cancer Research;
- 出版者：BioMed Central
- ISSN：1756-9966
文摘
Background Previous study showed that dsP53-285 has the capacity to induce tumor suppressor gene p53 expression by targeting promoter in non-human primates’ cells. And it is well known that TP53 gene is frequently mutant or inactivated in human bladder cancer. Hereby, whether this small RNA can activate the expression of wild-type p53 and inhibit human bladder cancer cells remains to be elucidated.